SCHEMBL21660533

SCHEMBL21660533

BN(c1noc2ccc(C)cc12)S(=O)(=O)c1cc(CC)ccc1OC

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.41
▸ BRD4 O60885 3/20 0.40
▸ KAT7 O95251 4/20 0.40
▸ KAT6A Q92794 4/20 0.40
▸ KAT6B Q8WYB5 3/20 0.40
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ MAPT P10636 4/20 0.39
▸ KAT5 Q92993 2/20 0.39
▸ KAT8 Q9H7Z6 2/20 0.39
▸ TSHR P16473 1/20 0.39
▸ MCOLN3 Q8TDD5 1/20 0.39
▸ TP53 P04637 1/20 0.38
▸ ALPL P05186 1/20 0.37
▸ BRD2 P25440 1/20 0.37
▸ BRD3 Q15059 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21596794 0.81 MAPT (0.37) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL31605548 0.81 MAPT (0.37) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL24429771 0.80 KAT7 (0.42) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL21596823 0.78 KAT6A (0.59) BRD4KAT7KAT6AKAT6BKAT5
SCHEMBL21660434 0.76 MAPT (0.43) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL24429773 0.76 KAT7 (0.41) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL24429772 0.74 KAT6A (0.39) POLBKAT7KAT6AKAT6BMEN1
SCHEMBL24429774 0.74 KAT7 (0.39) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL28514884 0.74 BRD4 (0.38) POLBBRD4KAT7KAT6AKAT6B
SCHEMBL29652474 0.74 BRD4 (0.38) POLBBRD4KAT7KAT6AKAT6B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 — — US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 POLB 3605/4885BRD4 1909/4885KAT7 490/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 POLB 3604/4885BRD4 1913/4885KAT7 490/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback