Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | APEX1 | P27695 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | P4HTM | Q9NXG6 | 9/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22242767 | 0.88 | LMNA (0.58) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL13850133 | 0.87 | POLB (0.68) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL21646019 | 0.85 | ALDH1A1 (0.78) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL3081741 | 0.84 | POLB (0.64) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL24892187 | 0.83 | RAB9A (0.71) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL13210529 | 0.83 | RAB9A (0.71) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL30182474 | 0.83 | RAB9A (0.71) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL13210581 | 0.83 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL30834320 | 0.83 | ALDH1A1 (1.00) | ALDH1A1RAB9ANPC1KDM4EPOLB | |
| SCHEMBL137276 | 0.82 | POLB (1.00) | RAB9ANPC1KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240308971-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2024-09-19 | — | — | US | disclosed |
| US-20210309630-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2021-10-07 | — | — | US | disclosed |
| WO-2020028814-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2020-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309630-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | WEE1, WEE2, PAXBP1 | ALDH1A1 4555/4885RAB9A 2015/4885NPC1 4722/4885 |
| US-20240308971-A1 | ALLOSTERIC INHIBITOR OF WEE1 KINASE | WEE1, WEE2, PPME1 | ALDH1A1 4492/4885RAB9A 3160/4885NPC1 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.