Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30675618 | 0.83 | TSHR (0.51) | TSHRHPGDKDM4EALDH1A1ENPP1 | |
| SCHEMBL20679612 | 0.83 | TSHR (0.51) | TSHRHPGDKDM4EALDH1A1ENPP1 | |
| SCHEMBL11802375 | 0.80 | PKM (0.59) | TSHRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL30675577 | 0.80 | PKM (0.59) | TSHRKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL26799 | 0.78 | KMT2A (0.58) | TSHRKDM4EALDH1A1ERCC1ERCC4 | |
| SCHEMBL21765862 | 0.77 | MEN1 (0.54) | ALDH1A1KMT2AMEN1RAB9ASMN1; SMN2 | |
| SCHEMBL18117790 | 0.77 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1HSD17B14EGFR | |
| SCHEMBL8857426 | 0.76 | POLB (0.48) | KDM4EALDH1A1ERCC1ERCC4KMT2A | |
| SCHEMBL8857854 | 0.75 | KDM4C (0.66) | TSHRHPGDKDM4EALDH1A1KMT2A | |
| SCHEMBL10865344 | 0.74 | CYP1A1 (0.60) | TSHRHPGDKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020028724-A1 | SUBSTITUTED-3H-IMIDAZO[4,5-C]PYRIDINE AND 1H-PYRROLO[2,3-C]PYRIDINE SERIES OF NOVEL ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE-1 (ENPP1) AND STIMULATOR FOR INTERFERON GENES (STING) MODULATORS AS CANCER IMMUNOTHERAPEUTICS | Stingray Therapeutics, Inc. (US) | 2020-02-06 | — | — | WO | disclosed |