Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166533 | 0.85 | TP53 (0.45) | HSD11B1TP53PPARDPPARACYP1A2 | |
| SCHEMBL280301 | 0.77 | TP53 (0.44) | HSD11B1TP53PPARDPPARACYP1A2 | |
| SCHEMBL264117 | 0.75 | TP53 (0.42) | HSD11B1TP53PPARDPPARAF2RL3 | |
| SCHEMBL1553917 | 0.75 | NPC1 (0.54) | PPARDPPARAALDH1A1NPC1 | |
| SCHEMBL379217 | 0.74 | SMN1; SMN2 (0.51) | TP53PPARDALDH1A1TRPM8NPC1 | |
| SCHEMBL2309205 | 0.73 | ALDH1A1 (0.60) | PPARDPPARACYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3965973 | 0.73 | PPARD (0.41) | HSD11B1TP53PPARDPPARACYP3A4 | |
| SCHEMBL2448126 | 0.73 | HSD11B1 (0.45) | HSD11B1ALDH1A1 | |
| SCHEMBL2166925 | 0.72 | PPARD (0.50) | HSD11B1TP53PPARDPPARACYP3A4 | |
| SCHEMBL2463067 | 0.72 | HSD11B1 (0.39) | HSD11B1PPARDPPARACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110184186-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2011-07-28 | — | — | US | disclosed |
| US-7982050-B2 | Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2011-07-19 | — | — | US | disclosed |
| EP-1501811-B1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | SEOUL NAT UNIV IND FOUNDATION (KR) | 2009-07-15 | — | — | EP | disclosed |
| US-20090118516-A1 | Process for preparing ligands of ppardelta and the intermediate compounds for preparing the same | Kang, Heon Joong (KR) | 2009-05-07 | — | — | US | disclosed |
| US-20070179300-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-08-02 | — | — | US | disclosed |
| US-7241901-B2 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-07-10 | — | — | US | disclosed |
| WO-2006121223-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEON JOONG (KR) | 2006-11-16 | — | — | WO | disclosed |
| EP-1501811-A4 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEONJOONG (KR) | 2006-02-08 | — | — | EP | disclosed |
| US-20050176785-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2005-08-11 | — | — | US | disclosed |
| EP-1501811-A1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | Kang, Heonjoong (KR) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003106442-A1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEONJOONG (KR) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179300-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | PPARD, PPARG, PPARA | HSD11B1 8/4885TP53 1164/4885PPARD 1/4885 |
| US-20110184186-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | PPARG, PPARD, PPARA | HSD11B1 23/4885TP53 1473/4885PPARD 2/4885 |
| US-20090118516-A1 | Process for preparing ligands of ppardelta and the intermediate compounds for preparing the same | PPARG, PPARD, PPARA | HSD11B1 23/4885TP53 1473/4885PPARD 2/4885 |
| US-20050176785-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | PPARD, PPARG, PPARA | HSD11B1 8/4885TP53 1164/4885PPARD 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.