Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 1/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2166493 | 0.85 | HSD11B1 (0.43) | TP53HSD11B1PPARDPPARACYP1A2 | |
| SCHEMBL6621280 | 0.82 | CTSK (0.42) | TP53HSD11B1PPARDPPARATRPA1 | |
| SCHEMBL5017179 | 0.82 | TP53 (0.38) | TP53PPARDPPARACYP3A4ALDH1A1 | |
| SCHEMBL4011426 | 0.78 | HTR2C (0.52) | ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL280301 | 0.77 | TP53 (0.44) | TP53HSD11B1PPARDPPARACYP1A2 | |
| SCHEMBL14017886 | 0.75 | MPL (0.43) | HSD11B1PPARDPPARAALDH1A1MPL | |
| SCHEMBL21879813 | 0.75 | PPARD (0.54) | TP53PPARDPPARACYP3A4ALDH1A1 | |
| SCHEMBL264117 | 0.75 | TP53 (0.42) | TP53HSD11B1PPARDPPARAF2RL3 | |
| SCHEMBL977726 | 0.75 | MAPT (0.59) | PPARDPPARAALDH1A1NPC1MAPT | |
| SCHEMBL2413521 | 0.74 | SMN1; SMN2 (0.51) | TP53PPARDALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431715-B2 | Thiazole compound (as PPARδ) ligand and pharmaceutical, cosmetic and health food comprised thereof | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2013-04-30 | — | — | US | disclosed |
| US-8236831-B2 | Thiazole compound (as PPARδ) ligand and pharmaceutical, cosmetic and health food comprised thereof | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2012-08-07 | — | — | US | disclosed |
| US-20120197024-A1 | Thiazole Compound (as PPAR delta) Ligand and Pharmaceutical, Cosmetic and Health Food Comprised Thereof | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2012-08-02 | — | — | US | disclosed |
| EP-1841748-B1 | ORGANOSELENIUM CONTAINING COMPOUNDS AND THEIR USE | SEOUL NAT UNIV IND FOUNDATION (KR) | 2011-12-28 | — | — | EP | disclosed |
| US-20110184186-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2011-07-28 | — | — | US | disclosed |
| US-7982050-B2 | Process for preparing ligands of PPARdelta and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2011-07-19 | — | — | US | disclosed |
| US-20100041723-A1 | Thiazole Compound (as PPAR delta) Ligand and Pharmaceutical, Cosmetic and Health Food Comprised Thereof | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2010-02-18 | — | — | US | disclosed |
| EP-2104666-A1 | THIAZOLE COMPOUND (AS PPARdelta) LIGAND AND PHARMACEUTICAL, COSMETIC AND HEALTH FOOD COMPRISED THEREOF | Seoul National University Industry Foundation (KR) | 2009-09-30 | — | — | EP | disclosed |
| EP-1501811-B1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | SEOUL NAT UNIV IND FOUNDATION (KR) | 2009-07-15 | — | — | EP | disclosed |
| US-20090118516-A1 | Process for preparing ligands of ppardelta and the intermediate compounds for preparing the same | Kang, Heon Joong (KR) | 2009-05-07 | — | — | US | disclosed |
| US-7241901-B2 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2007-07-10 | — | — | US | disclosed |
| WO-2006121223-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEON JOONG (KR) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006091047-A1 | THIAZOLE DERIVATIVES AS PPAR DELTA LIGANDS AND THEIR MANUFACTURING PROCESS | KANG HEONJOONG (KR) | 2006-08-31 | — | — | WO | disclosed |
| WO-2006071103-A1 | ORGANOSELENIUM CONTAINING COMPOUNDS AND THEIR USE | KANG HEONJOONG (KR) | 2006-07-06 | — | — | WO | disclosed |
| EP-1501811-A4 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEONJOONG (KR) | 2006-02-08 | — | — | EP | disclosed |
| US-20050176785-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) | 2005-08-11 | — | — | US | disclosed |
| CN-1649854-A | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | HEONJOONG KANG (KR) | 2005-08-03 | — | — | CN | disclosed |
| EP-1501811-A1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | Kang, Heonjoong (KR) | 2005-02-02 | — | — | EP | disclosed |
| US-20050014812-A1 | Benzimidazole compounds | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2005-01-20 | — | — | US | disclosed |
| WO-2003106442-A1 | PROCESS FOR PREPARING THIAZOLE DERIVATIVE AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | KANG HEONJOONG (KR) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041723-A1 | Thiazole Compound (as PPAR delta) Ligand and Pharmaceutical, Cosmetic and Health Food Comprised Thereof | PPARD, PPARG, PPARA | TP53 480/4885HSD11B1 262/4885PPARD 1/4885 |
| US-20110184186-A1 | PROCESS FOR PREPARING LIGANDS OF PPARDELTA AND THE INTERMEDIATE COMPOUNDS FOR PREPARING THE SAME | PPARG, PPARD, PPARA | TP53 1473/4885HSD11B1 23/4885PPARD 2/4885 |
| US-20120197024-A1 | Thiazole Compound (as PPAR delta) Ligand and Pharmaceutical, Cosmetic and Health Food Comprised Thereof | PPARD, PPARG, PPARA | TP53 480/4885HSD11B1 262/4885PPARD 1/4885 |
| US-20090118516-A1 | Process for preparing ligands of ppardelta and the intermediate compounds for preparing the same | PPARG, PPARD, PPARA | TP53 1473/4885HSD11B1 23/4885PPARD 2/4885 |
| US-20050014812-A1 | Benzimidazole compounds | SLC5A1, SLC5A2, G6PD | TP53 1741/4885HSD11B1 888/4885PPARD 290/4885 |
| US-20050176785-A1 | Process for preparing thiazole derivative and the intermediate compounds for preparing the same | PPARD, PPARG, PPARA | TP53 1164/4885HSD11B1 8/4885PPARD 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.