Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | PDE9A | O76083 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24469533 | 0.84 | ALDH1A1 (0.46) | ALDH1A1LMNAL3MBTL1POLBPDE9A | |
| SCHEMBL21667372 | 0.83 | ALDH1A1 (0.66) | ALDH1A1LMNAL3MBTL1POLBPDE9A | |
| SCHEMBL21667378 | 0.82 | ALDH1A1 (0.45) | ALDH1A1LMNAL3MBTL1POLBPDE9A | |
| SCHEMBL21667332 | 0.78 | CYP3A4 (0.49) | ALDH1A1LMNAL3MBTL1POLBKMT2A | |
| SCHEMBL16322370 | 0.78 | CYP3A4 (0.62) | ALDH1A1LMNAL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL16322368 | 0.78 | CYP3A4 (0.62) | ALDH1A1LMNAL3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL20716038 | 0.78 | CYP3A4 (0.61) | ALDH1A1LMNAL3MBTL1POLBPDE9A | |
| SCHEMBL21667203 | 0.78 | POLB (0.61) | ALDH1A1LMNAL3MBTL1POLBPDE9A | |
| SCHEMBL21667306 | 0.76 | CYP3A4 (0.50) | ALDH1A1LMNAL3MBTL1POLBPDE9A | |
| SCHEMBL21667381 | 0.76 | PDE5A (0.48) | ALDH1A1LMNAL3MBTL1POLBPDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022111498-A1 | PYRIMIDINEDIONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2022-06-02 | — | — | WO | disclosed |
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |