Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CLPP | Q16740 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667372 | 0.85 | ALDH1A1 (0.66) | POLBLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL21667214 | 0.80 | SMN1; SMN2 (0.47) | LMNAL3MBTL1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL16321238 | 0.78 | SMN1; SMN2 (0.41) | POLBLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16321236 | 0.78 | SMN1; SMN2 (0.41) | POLBLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL21667369 | 0.78 | ALDH1A1 (0.64) | POLBLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL14612437 | 0.67 | ALDH1A1 (0.62) | ALDH1A1MAPTSMN1; SMN2TP53TSHR | |
| SCHEMBL21667218 | 0.66 | KMT2A (0.42) | POLBLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL21667281 | 0.66 | EGFR (0.53) | MAPTMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL21723553 | 0.65 | POLB (0.50) | POLBLMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL16322281 | 0.64 | KMT2A (0.57) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |