Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 5/20 | 0.34 |
| ▸ | BRAF | P15056 | 5/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667386 | 0.83 | P2RX3 (0.39) | ALDH1A1LMNAL3MBTL1POLBP2RX3 | |
| SCHEMBL21667369 | 0.82 | ALDH1A1 (0.64) | ALDH1A1LMNAL3MBTL1POLBCYP3A4 | |
| SCHEMBL16324266 | 0.79 | CYP3A4 (0.60) | CYP3A4CYP2B6P2RX3PDE2AHTT | |
| SCHEMBL16324269 | 0.79 | CYP3A4 (0.60) | CYP3A4CYP2B6P2RX3PDE2AHTT | |
| SCHEMBL21667332 | 0.79 | CYP3A4 (0.49) | ALDH1A1LMNAL3MBTL1POLBCYP3A4 | |
| SCHEMBL24469533 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LMNAL3MBTL1POLBCYP3A4 | |
| SCHEMBL20716038 | 0.76 | CYP3A4 (0.61) | ALDH1A1LMNAL3MBTL1POLBCYP3A4 | |
| SCHEMBL21667176 | 0.76 | CYP3A4 (0.49) | ALDH1A1LMNAL3MBTL1CYP3A4CYP2B6 | |
| SCHEMBL21667306 | 0.75 | CYP3A4 (0.50) | ALDH1A1LMNAL3MBTL1POLBCYP3A4 | |
| SCHEMBL21667347 | 0.75 | CYP3A4 (0.50) | ALDH1A1LMNAL3MBTL1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |