Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667203 | 0.85 | POLB (0.61) | ALDH1A1LMNAL3MBTL1POLBMAPT | |
| SCHEMBL21667369 | 0.83 | ALDH1A1 (0.64) | ALDH1A1LMNAL3MBTL1POLBMAPT | |
| SCHEMBL21667215 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1LMNAL3MBTL1MAPTNPSR1 | |
| SCHEMBL21667218 | 0.78 | KMT2A (0.42) | ALDH1A1LMNAL3MBTL1POLBMAPT | |
| SCHEMBL16322198 | 0.77 | SMN1; SMN2 (0.44) | ALDH1A1LMNAL3MBTL1POLBMAPT | |
| SCHEMBL16322196 | 0.77 | SMN1; SMN2 (0.44) | ALDH1A1LMNAL3MBTL1POLBMAPT | |
| SCHEMBL21667387 | 0.77 | PGR (0.47) | ALDH1A1LMNAL3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL21667281 | 0.73 | EGFR (0.53) | MAPTNPSR1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21667187 | 0.69 | SMN1; SMN2 (0.54) | ALDH1A1LMNAL3MBTL1MAPTNPSR1 | |
| SCHEMBL21667283 | 0.68 | KMT2A (0.50) | ALDH1A1POLBMAPTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3702352-A1 | PYRIMIDINEDIONE COMPOUND AGAINST CARDIAC CONDITIONS | Myokardia, Inc. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |