Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 6/20 | 0.33 |
| ▸ | BRAF | P15056 | 6/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21667378 | 0.83 | ALDH1A1 (0.45) | P2RX3KDM4EALDH1A1PDE2ANPSR1 | |
| SCHEMBL16323079 | 0.80 | PDE2A (0.44) | P2RX3PDE2ASMN1; SMN2 | |
| SCHEMBL16323078 | 0.80 | PDE2A (0.44) | P2RX3PDE2ASMN1; SMN2 | |
| SCHEMBL21667303 | 0.70 | PDE9A (0.46) | PDE2AMAPTPDE9ALMNA | |
| SCHEMBL18656445 | 0.67 | KDM4E (0.41) | KDM4EALDH1A1PDE2ANPSR1MEN1 | |
| SCHEMBL21667179 | 0.67 | PGR (0.44) | KDM4EALDH1A1MAPTHTTLMNA | |
| SCHEMBL16324269 | 0.67 | CYP3A4 (0.60) | P2RX3PDE2AHTTSMN1; SMN2 | |
| SCHEMBL16324266 | 0.67 | CYP3A4 (0.60) | P2RX3PDE2AHTTSMN1; SMN2 | |
| SCHEMBL21667314 | 0.66 | CDK1 (0.44) | KDM4EALDH1A1NPSR1MEN1MAPT | |
| SCHEMBL3669352 | 0.66 | PDE2A (0.41) | PDE2ANPSR1HTTKITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010910-B1 | PYRIMIDINEDIONE COMPOUNDS AGAINST CARDIAC CONDITIONS | MYOKARDIA INC (US) | 2020-02-05 | — | — | EP | disclosed |