Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.62 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4701073 | 0.88 | MAPT (0.77) | LMNASMN1; SMN2CYP2C19AKR1C3AKR1C1 | |
| SCHEMBL21669903 | 0.88 | MAPT (0.77) | LMNASMN1; SMN2CYP2C19AKR1C3AKR1C1 | |
| SCHEMBL610121 | 0.88 | MAPT (0.77) | LMNASMN1; SMN2CYP2C19AKR1C3AKR1C1 | |
| SCHEMBL19563515 | 0.86 | MAPT (0.59) | LMNASMN1; SMN2AKR1C3AKR1C1MAPT | |
| SCHEMBL14538823 | 0.86 | ALDH1A1 (0.70) | LMNASMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL10282884 | 0.86 | ALDH1A1 (0.70) | LMNASMN1; SMN2MAPTALDH1A1MAPK1 | |
| SCHEMBL21670254 | 0.86 | LMNA (0.70) | LMNASMN1; SMN2CYP2C19AKR1C3AKR1C1 | |
| SCHEMBL21670261 | 0.86 | LMNA (0.70) | LMNASMN1; SMN2CYP2C19AKR1C3AKR1C1 | |
| SCHEMBL27791834 | 0.85 | LMNA (0.52) | LMNASMN1; SMN2CYP2C19HTTALDH1A1 | |
| SCHEMBL25269754 | 0.84 | AKR1C3 (0.80) | LMNASMN1; SMN2AKR1C3AKR1C1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192816-A1 | COMPOUNDS AS C5AR INHIBITORS | Kira Pharmaceuticals (Suzhou) Ltd. (CN) | 2023-06-14 | — | — | EP | disclosed |
| WO-2020028482-A1 | SMALL MOLECULES THAT SENSITIZE HIV-1 INFECTED CELLS TO ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-02-06 | — | — | WO | disclosed |