Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.42 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | KAT7 | O95251 | 1/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9017801 | 0.87 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3KCNH2SLC6A1 | |
| SCHEMBL4779495 | 0.86 | SLC6A1 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2SLC6A1 | |
| SCHEMBL26599052 | 0.84 | KDM2B (0.46) | SLC6A2SLC6A4SLC6A3CHRM1TSHR | |
| SCHEMBL30606587 | 0.84 | KDM2B (0.46) | SLC6A2SLC6A4SLC6A3CHRM1TSHR | |
| SCHEMBL21670367 | 0.77 | TNKS (0.58) | — | |
| SCHEMBL13631069 | 0.76 | KMT2A (0.38) | SLC6A2SLC6A4SLC6A3KCNH2SLC6A1 | |
| SCHEMBL26085824 | 0.75 | KDM4E (0.49) | SLC6A1SLC6A11TSHRLMNASMN1; SMN2 | |
| SCHEMBL4748847 | 0.75 | KAT7 (0.44) | SLC6A2SLC6A4SLC6A3KCNH2OPRK1 | |
| SCHEMBL4776325 | 0.74 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2SLC6A1 | |
| SCHEMBL3963692 | 0.73 | KDM2B (0.55) | LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156832-A2 | RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |