Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL127659 | 1.00 | HCAR2 (0.41) | HCAR2FFAR3HDAC1HDAC2HDAC3 | |
| SCHEMBL62835 | 0.87 | — | — | |
| Benzene SCHEMBL6039284 | 0.84 | LMNA (0.39) | HCAR2LMNAALDH1A1KMT2A | |
| SCHEMBL11329991 | 0.83 | — | — | |
| Ammonia Solution, Strong SCHEMBL9511888 | 0.83 | — | — | |
| Ethane SCHEMBL10935052 | 0.83 | — | — | |
| Bicarbonate SCHEMBL316752 | 0.82 | ALDH1A1 (0.50) | HCAR2ALDH1A1TDP1AKR1B1ATM | |
| Bicarbonate SCHEMBL1261114 | 0.82 | ALDH1A1 (0.50) | HCAR2ALDH1A1TDP1AKR1B1ATM | |
| Methacrylic Acid SCHEMBL19510257 | 0.82 | TSHR (0.41) | HCAR2FFAR3HDAC1HDAC2HDAC3 | |
| Bicarbonate SCHEMBL10886257 | 0.80 | NAAA (0.48) | HCAR2ALDH1A1TDP1AKR1B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 822 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3797103-B1 | A NOVEL PROCESS FOR THE PREPARATION OF ANTHRANILIC DIAMIDES | PI INDUSTRIES LTD (IN) | 2026-04-08 | — | — | EP | claimed |
| EP-3823953-B1 | A NOVEL PROCESS FOR THE PREPARATION OF ANTHRANILIC DIAMIDES | PI INDUSTRIES LTD (IN) | 2024-09-11 | — | — | EP | claimed |
| US-20240206461-A1 | DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | ENCAPSYS, LLC (US) | 2024-06-27 | — | — | US | claimed |
| EP-4369931-A2 | DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | Encapsys, LLC (US) | 2024-05-22 | — | — | EP | claimed |
| EP-4370644-A1 | CONSUMER PRODUCTS COMPRISING DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | The Procter & Gamble Company (US) | 2024-05-22 | — | — | EP | claimed |
| EP-4355848-A1 | CONSUMER PRODUCTS COMPRISING DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | The Procter & Gamble Company (US) | 2024-04-24 | — | — | EP | claimed |
| EP-4355472-A1 | DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | Encapsys, LLC (US) | 2024-04-24 | — | — | EP | claimed |
| US-20240122176-A1 | DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | ENCAPSYS, LLC (US) | 2024-04-18 | — | — | US | claimed |
| US-20230056295-A1 | CONSUMER PRODUCTS COMPRISING DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | THE PROCTER & GAMBLE COMPANY | 2023-02-23 | — | — | US | claimed |
| WO-2023288239-A1 | CONSUMER PRODUCTS COMPRISING DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | THE PROCTER & GAMBLE COMPANY (US) | 2023-01-19 | — | — | WO | claimed |
| EP-0328725-B1 | Polycarboxylic acids with higher thickening capacity and better clarity | GOODRICH CO B F (US) | 1995-05-03 | — | — | EP | claimed |
| EP-0279892-B1 | Polycarboxylic acids with small amount of residual monomer | GOODRICH CO B F (US) | 1994-07-13 | — | — | EP | claimed |
| EP-0299025-B1 | IMPROVED HAIR TREATING RESINS | ISP INVESTMENTS INC. (US) | 1993-05-19 | — | — | EP | claimed |
| US-4873274-A | In-mold coating powders with two initiators or 1,1-di(t-butylperoxy)-3,3,5-trimethylcyclohexane as a single initiator | MORTON THIOKOL, INC. (US) | 1989-10-10 | — | — | US | claimed |
| EP-0299025-A4 | IMPROVED HAIR TREATING RESINS. | GAF CORP (US) | 1989-05-30 | — | — | EP | claimed |
| EP-0309088-A2 | In-mold coating powder containing 1,1'-di(t-butylperoxy)-3,3,5-trimethylcyclohexane as an initiator. | MORTON INTERNATIONAL, INC. (US) | 1989-03-29 | — | — | EP | claimed |
| EP-0299025-A1 | IMPROVED HAIR TREATING RESINS. | GAF CORP (US) | 1989-01-18 | — | — | EP | claimed |
| WO-1988005442-A1 | IMPROVED HAIR TREATING RESINS | GAF CORPORATION (US) | 1988-07-28 | — | — | WO | claimed |
| US-4689379-A | TERPOLYMER OF VINYL ESTER, ALKYL MALEATE HALF ESTER AND ACRYLATE OR METHACRYLATE ESTER | GAF CORPORATION (US) | 1987-08-25 | — | — | US | claimed |
| US-4396527-A | Aqueous emulsions of organic peroxides | NIPPON OIL AND FATS CO., LTD. (JP) | 1983-08-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240206461-A1 | DELIVERY PARTICLES WITH HIGH CORE:WALL RATIOS | CETP, CHMP4B, HDLBP | HCAR2 1190/4885FFAR3 1445/4885HDAC1 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.