Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL216807 | 1.00 | HCAR2 (0.41) | HCAR2FFAR3HDAC1HDAC2HDAC3 | |
| SCHEMBL62835 | 0.87 | — | — | |
| Benzene SCHEMBL6039284 | 0.84 | LMNA (0.39) | HCAR2LMNAALDH1A1KMT2A | |
| SCHEMBL11329991 | 0.83 | — | — | |
| Ammonia Solution, Strong SCHEMBL9511888 | 0.83 | — | — | |
| Ethane SCHEMBL10935052 | 0.83 | — | — | |
| Bicarbonate SCHEMBL316752 | 0.82 | ALDH1A1 (0.50) | HCAR2ALDH1A1TDP1AKR1B1ATM | |
| Bicarbonate SCHEMBL1261114 | 0.82 | ALDH1A1 (0.50) | HCAR2ALDH1A1TDP1AKR1B1ATM | |
| Methacrylic Acid SCHEMBL19510257 | 0.82 | TSHR (0.41) | HCAR2FFAR3HDAC1HDAC2HDAC3 | |
| Bicarbonate SCHEMBL10886257 | 0.80 | NAAA (0.48) | HCAR2ALDH1A1TDP1AKR1B1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 615 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118791656-A | EVOH resin with high barrier property, preparation method and application thereof | 万华化学集团股份有限公司 | 2024-10-18 | — | — | CN | claimed |
| WO-2023239537-A1 | NON-LINEAR VINYLIDENE FLUORIDE COPOLYMERS | ARKEMA INC. (US) | 2023-12-14 | — | — | WO | claimed |
| CN-117177808-A | Delivery particles with high core to wall ratio | 恩盖普有限公司 | 2023-12-05 | — | — | CN | claimed |
| CN-112469687-B | New method for preparing o-carboxamido benzamide compound | PI工业有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-116583587-A | Consumer product comprising delivery particles with high core to wall ratio | 宝洁公司 | 2023-08-11 | — | — | CN | claimed |
| CN-116546955-A | Consumer product comprising delivery particles with high core to wall ratio | 宝洁公司 | 2023-08-04 | — | — | CN | claimed |
| CN-115715301-A | Process for preparing a composition comprising at least a mixture of at least one peroxydicarbonate and at least one peroxyester | 阿科玛法国公司 | 2023-02-24 | — | — | CN | claimed |
| CN-115702172-A | Aqueous composition comprising at least one peroxydicarbonate and at least one peroxyester in the form of an emulsion | 阿科玛法国公司 | 2023-02-14 | — | — | CN | claimed |
| CN-114341202-A | Treatment process based on polymeric dispersions using specific organic peroxides | 阿科玛法国公司 | 2022-04-12 | — | — | CN | claimed |
| CN-112469687-A | Novel method for preparing o-formamido benzamide compound | PI工业有限公司 | 2021-03-09 | — | — | CN | claimed |
| US-20040249097-A1 | Stable and pure organic peroxides produced outside of reactors by forming an aqueous emulsion of the peroxy reactants; addition polymers are solvent- and plasticizer-free and of high quality | OXY VINYLS, L.P. | 2004-12-09 | — | — | US | claimed |
| US-20040215034-A1 | SUCH AS DIETHYL PEROXYDICARBONATE; HOMOGENATION; SOLVENT/PLASTICIZER-FREE | OXY VINYLS, LP | 2004-10-28 | — | — | US | claimed |
| EP-1124787-A1 | LIQUID COMPOSITION POLYMERIZABLE INTO ORGANIC GLASSES HAVING GOOD OPTICAL AND PHYSICO-MECHANICAL PROPERTIES | Great Lakes Chemical (Europe) GmbH (CH) | 2001-08-22 | — | — | EP | claimed |
| WO-2001014459-A1 | RADICAL-CURABLE ADHESIVE COMPOSITIONS, REACTION PRODUCTS OF WHICH DEMONSTRATE SUPERIOR RESISTANCE TO THERMAL DEGRADATION | LOCTITE CORPORATION (US) | 2001-03-01 | — | — | WO | claimed |
| EP-0950082-A4 | REDUCING VOID FORMATION IN CURABLE ADHESIVE FORMULATIONS | QUANTUM MATERIALS INC (US) | 2000-07-12 | — | — | EP | claimed |
| WO-2000031149-A1 | RADICAL-CURABLE ADHESIVE COMPOSITIONS, REACTION PRODUCTS OF WHICH DEMONSTRATE SUPERIOR RESISTANCE TO THERMAL DEGRADATION | LOCTITE CORPORATION (US) | 2000-06-02 | — | — | WO | claimed |
| WO-2000031165-A1 | RADICAL-CURABLE ADHESIVE COMPOSITIONS, REACTION PRODUCTS OF WHICH DEMONSTRATE SUPERIOR RESISTANCE TO THERMAL DEGRADATION | LOCTITE CORPORATION (US) | 2000-06-02 | — | — | WO | claimed |
| WO-2000027794-A1 | LIQUID COMPOSITION POLYMERIZABLE INTO ORGANIC GLASSES HAVING GOOD OPTICAL AND PHYSICO-MECHANICAL PROPERTIES | GREAT LAKES CHEMICAL (EUROPE) GMBH (CH) | 2000-05-18 | — | — | WO | claimed |
| EP-0950082-A1 | REDUCING VOID FORMATION IN CURABLE ADHESIVE FORMULATIONS | QUANTUM MATERIALS, INC. (US) | 1999-10-20 | — | — | EP | claimed |
| WO-1998030647-A1 | REDUCING VOID FORMATION IN CURABLE ADHESIVE FORMULATIONS | QUANTUM MATERIALS, INC. (US) | 1998-07-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040215034-A1 | SUCH AS DIETHYL PEROXYDICARBONATE; HOMOGENATION; SOLVENT/PLASTICIZER-FREE | HAO2, GPX4, HDHD5 | HCAR2 2175/4885FFAR3 502/4885HDAC1 3570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.