Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7704551 | 0.88 | MAPT (0.56) | TSHRPOLBKDM4ERAB9AMAPT | |
| SCHEMBL14266385 | 0.88 | KMT2A (0.53) | TSHRPOLBLMNANPC1RAB9A | |
| SCHEMBL25340861 | 0.83 | MEN1 (0.51) | TSHRPOLBKDM4ELMNARAB9A | |
| SCHEMBL14416597 | 0.81 | TSHR (0.61) | TSHRLMNAMAPTL3MBTL1GAA | |
| SCHEMBL5022147 | 0.81 | GAA (0.50) | DHODHPOLBLMNAMAPTGAA | |
| SCHEMBL20560160 | 0.79 | GAA (0.51) | GAAALDH1A1ABCB11PTGS1PTGS2 | |
| SCHEMBL8773868 | 0.79 | ALB (0.47) | TSHRPOLBKDM4ENPC1RAB9A | |
| SCHEMBL14416594 | 0.79 | TSHR (0.46) | TSHRPOLBKDM4ENPC1RAB9A | |
| SCHEMBL11436764 | 0.78 | KMT2A (0.53) | KDM4ELMNAGAAALDH1A1ABCB11 | |
| SCHEMBL12637722 | 0.78 | ADORA3 (0.43) | TSHRPOLBNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866426-B2 | Benzothiazole compounds and uses thereof | INCYTE CORPORATION (US) | 2024-01-09 | — | — | US | disclosed |
| US-20210171518-A1 | BENZOTHIAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-06-10 | — | — | US | disclosed |
| US-20210171518-A1 | BENZOTHIAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2021-06-10 | — | — | US | disclosed |
| US-10899755-B2 | Benzothiazole compounds and uses thereof | INCYTE CORPORATION (US) | 2021-01-26 | — | — | US | disclosed |
| US-20200048241-A1 | BENZOTHIAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2020-02-13 | — | — | US | disclosed |
| US-20200048241-A1 | BENZOTHIAZOLE COMPOUNDS AND USES THEREOF | INCYTE CORPORATION | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10899755-B2 | Benzothiazole compounds and uses thereof | PDXK, PCK1, HIPK1 | TSHR 4802/4885DHODH 1430/4885POLB 2080/4885 |
| US-20210171518-A1 | BENZOTHIAZOLE COMPOUNDS AND USES THEREOF | PDXK, PCK1, HIPK1 | TSHR 4802/4885DHODH 1430/4885POLB 2080/4885 |
| US-20200048241-A1 | BENZOTHIAZOLE COMPOUNDS AND USES THEREOF | PDXK, PCK1, HIPK1 | TSHR 4802/4885DHODH 1430/4885POLB 2080/4885 |
| US-11866426-B2 | Benzothiazole compounds and uses thereof | PDXK, PCK1, HIPK1 | TSHR 4802/4885DHODH 1430/4885POLB 2080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.