Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | COMT | P21964 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645817 | 0.89 | VCAM1 (0.55) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL27212775 | 0.84 | VCAM1 (0.51) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL22081923 | 0.84 | MAPT (0.52) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL30158975 | 0.84 | VCAM1 (0.51) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL30159180 | 0.84 | MAPT (0.52) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL23970644 | 0.84 | VCAM1 (0.48) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL30159160 | 0.84 | VCAM1 (0.48) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL10608607 | 0.83 | LMNA (0.53) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL753386 | 0.83 | KDM4E (0.51) | VCAM1MAPTKDM4EPOLBMAPK1 | |
| SCHEMBL7573734 | 0.83 | TPMT (0.54) | VCAM1MAPTKDM4EPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112789087-B | Benzimidazole inhibitors of PAD enzymes | 百时美施贵宝公司 | 2024-08-13 | — | — | CN | disclosed |
| EP-3833439-B1 | BENZIMIDAZOLE INHIBITORS OF PAD ENZYMES | BRISTOL MYERS SQUIBB CO (US) | 2023-07-12 | — | — | EP | disclosed |
| US-20220348562-A1 | BENZIMIDAZOLE INHIBITORS OF PAD ENZYMES | BRISTOL MYERS SQUIBB CO (US) | 2022-11-03 | — | — | US | disclosed |
| EP-3833439-A1 | BENZIMIDAZOLE INHIBITORS OF PAD ENZYMES | Bristol-Myers Squibb Company (US) | 2021-06-16 | — | — | EP | disclosed |
| CN-112789087-A | Benzimidazole inhibitors of PAD enzymes | 百时美施贵宝公司 | 2021-05-11 | — | — | CN | disclosed |
| WO-2020033514-A1 | BENZIMIDAZOLE INHIBITORS OF PAD ENZYMES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220348562-A1 | BENZIMIDAZOLE INHIBITORS OF PAD ENZYMES | PADI4, PADI1, PADI2 | VCAM1 3115/4885MAPT 4649/4885KDM4E 137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.