Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 1/20 | 0.52 |
| ▸ | CTSB | P07858 | 1/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | CTSK | P43235 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23291895 | 0.90 | PLK1 (0.57) | PLK1CTSLCTSBCTSSCTSK | |
| SCHEMBL23780470 | 0.88 | HDAC6 (0.62) | PLK1LMNARAB9AHPGDHDAC4 | |
| SCHEMBL23791596 | 0.87 | PLK1 (0.55) | PLK1CTSLCTSBCTSSCTSK | |
| SCHEMBL23292046 | 0.85 | NPC1 (0.60) | CTSLCTSBCTSSCTSKLMNA | |
| SCHEMBL23791439 | 0.84 | RAB9A (0.53) | PLK1LMNATSHRNFKB1RAB9A | |
| SCHEMBL21683292 | 0.83 | HDAC6 (0.57) | HDAC4HDAC6HDAC1HDAC8MAPT | |
| SCHEMBL6565112 | 0.83 | L3MBTL1 (0.59) | PLK1TSHRMAPTPOLBKMT2A | |
| SCHEMBL21702519 | 0.83 | PLK1 (0.50) | PLK1CTSLCTSBCTSSCTSK | |
| SCHEMBL23791594 | 0.83 | TNKS (0.53) | PLK1CTSLCTSBCTSSCTSK | |
| SCHEMBL7074248 | 0.82 | PLK1 (0.57) | PLK1LMNATSHRNFKB1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | claimed |
| US-11945803-B2 | Modulators of RAS GTPase | TOSK, INC. (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3814343-B1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS INC (US) | 2023-01-11 | — | — | EP | disclosed |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. | 2021-09-09 | — | — | US | disclosed |
| WO-2020033413-A2 | MODULATORS OF RAS GTPASE | TOSK, INC. (US) | 2020-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11945803-B2 | Modulators of RAS GTPase | KRAS, HRAS, NRAS | PLK1 123/4885CTSL 2703/4885CTSB 807/4885 |
| US-20210276991-A1 | CARDIAC SARCOMERE INHIBITORS | TNNI3, TNNT2, MYLK2 | PLK1 1581/4885CTSL 2734/4885CTSB 3757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.