SCHEMBL2168454

SCHEMBL2168454

CS(=O)(=O)O.O=C(OCCO)c1ccccc1F

nearest known ligand 0.50

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ADRB2 known ✓ P07550 5/20 0.49
ADRB1 P08588 5/20 0.49
ADRB3 P13945 5/20 0.49
TP53 P04637 2/20 0.48
HTT P42858 1/20 0.48
ALDH1A1 P00352 3/20 0.47
TSHR P16473 4/20 0.47
TDP1 Q9NUW8 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
LMNA P02545 2/20 0.45
KMT2A Q03164 1/20 0.44
CYP3A4 P08684 1/20 0.44
MAPK1 P28482 1/20 0.44
KDM4E B2RXH2 1/20 0.44
GAA P10253 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2166055 0.83 KMT2A (0.51) HTTALDH1A1L3MBTL1LMNAKMT2A
SCHEMBL2166185 0.82 ALDH1A1 (0.50) ALDH1A1TDP1L3MBTL1KMT2AGAA
SCHEMBL18775946 0.81 ALDH1A1 (0.46) ADRB2ADRB1ADRB3TP53HTT
SCHEMBL2168384 0.81 NPC1 (0.46) ADRB2ADRB1ADRB3TP53HTT
SCHEMBL29540297 0.79 ALDH1A1 (0.55) TP53ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL14389377 0.79 ALDH1A1 (0.76) ADRB2ADRB1ADRB3TP53HTT
SCHEMBL36533 0.78 ALDH1A1 (0.67) TP53ALDH1A1TSHRTDP1L3MBTL1
SCHEMBL14430005 0.78 TSHR (0.56) ADRB2ADRB1ADRB3TP53HTT
Ethylene Glycol SCHEMBL2168458 0.78 GAA (0.53) TP53HTTALDH1A1TSHRKMT2A
SCHEMBL896931 0.77 TSHR (0.65) TP53ALDH1A1TSHRTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8383274-B2 Nonaqueous electrolyte solution for lithium battery, lithium battery using same, and formyloxy group-containing compound used therein UBE INDUSTRIES, LTD. (JP) 2013-02-26 US disclosed
US-20110183199-A1 NONAQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM BATTERY, LITHIUM BATTERY USING SAME, AND FORMYLOXY GROUP-CONTAINING COMPOUND USED THEREIN UBE INDUSTRIES, LTD. (JP) 2011-07-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110183199-A1 NONAQUEOUS ELECTROLYTE SOLUTION FOR LITHIUM BATTERY, LITHIUM BATTERY USING SAME, AND FORMYLOXY GROUP-CONTAINING COMPOUND USED THEREIN HCN2, KCNN2, KCNB1 ADRB2 2601/4885ADRB1 2792/4885ADRB3 3781/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.