SCHEMBL21687618

SCHEMBL21687618

N#Cc1cccc(-c2ccccc2[Si](c2ccccc2)(c2ccccc2)c2ccccc2)c1-n1c2ccccc2c2ccccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.35
ALDH1A1 P00352 4/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
TDP1 Q9NUW8 2/20 0.35
TSHR P16473 1/20 0.35
MAPT P10636 1/20 0.35
IMPDH2 P12268 1/20 0.33
KDM4E B2RXH2 2/20 0.33
ATM Q13315 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
STAT3 P40763 1/20 0.32
HIF1A Q16665 1/20 0.32
ELANE P08246 1/20 0.32
DUSP3 P51452 1/20 0.32
CA1 P00915 1/20 0.31
CA2 P00918 1/20 0.31
HTT P42858 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CNR2 P34972 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21687915 0.91 SMN1; SMN2 (0.34) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21687903 0.91 ALDH1A1 (0.32) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21687927 0.90 SMN1; SMN2 (0.34) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21687754 0.88 ALDH1A1 (0.32) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21687553 0.88 TDP2 (0.31) ALDH1A1KDM4E
SCHEMBL21687499 0.87 IMPDH2 (0.33) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21688015 0.87 KDM4E (0.33) ALDH1A1KDM4E
SCHEMBL21687901 0.86 ALDH1A1 (0.33) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21687648 0.86 ALDH1A1 (0.33) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1
SCHEMBL21687889 0.86 ALDH1A1 (0.35) SMN1; SMN2ALDH1A1MEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11201300-B2 Condensed cyclic compound and organic light-emitting device including condensed cyclic compound SAMSUNG ELECTRONICS CO., LTD. (KR) 2021-12-14 US disclosed
US-20200044168-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND SAMSUNG ELECTRONICS CO., LTD. (KR) 2020-02-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200044168-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND CRY1, CCNL2, CCNE2 SMN1; SMN2 4039/4885ALDH1A1 616/4885MEN1 669/4885
US-11201300-B2 Condensed cyclic compound and organic light-emitting device including condensed cyclic compound CRY1, CCNL2, CCNE2 SMN1; SMN2 4039/4885ALDH1A1 616/4885MEN1 669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.