SCHEMBL21687749

SCHEMBL21687749

N#Cc1ccc([Si](c2ccccc2)(c2ccccc2)c2ccccc2)c(-c2ccc(C#N)c(-n3c4ccccc4c4cc(C#N)ccc43)c2)c1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 2/20 0.33
RORC P51449 3/20 0.31
CYP11B1 P15538 1/20 0.31
CYP11B2 P19099 1/20 0.31
GABRA1 P14867 1/20 0.30
GABRG2 P18507 1/20 0.30
GABRB3 P28472 1/20 0.30
GABRA5 P31644 1/20 0.30
GABRA3 P34903 1/20 0.30
GABRA2 P47869 1/20 0.30
METAP2 P50579 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21688056 0.97 CYP11B1 (0.32) PTGER4CYP11B1CYP11B2GABRA1GABRG2
SCHEMBL21688105 0.94 PTGER4 (0.33) PTGER4RORCCYP11B1CYP11B2
SCHEMBL21688237 0.93 PTGER4 (0.33) PTGER4GABRA1GABRG2GABRB3GABRA5
SCHEMBL21688174 0.92 PTGER4 (0.33) PTGER4RORCCYP11B1CYP11B2
SCHEMBL21687663 0.91 PTGER4 (0.33) PTGER4RORC
SCHEMBL21687481 0.91 NR3C1 (0.31) CYP11B1CYP11B2
SCHEMBL21687685 0.90 PTGER4 (0.34) PTGER4RORC
SCHEMBL21688244 0.89 GABRA1 (0.34) PTGER4CYP11B1CYP11B2GABRA1GABRG2
SCHEMBL21688185 0.89 CYP11B1 (0.32) PTGER4CYP11B1CYP11B2
SCHEMBL21687674 0.88 PTGER4 (0.33) PTGER4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11201300-B2 Condensed cyclic compound and organic light-emitting device including condensed cyclic compound SAMSUNG ELECTRONICS CO., LTD. (KR) 2021-12-14 US disclosed
US-20200044168-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND SAMSUNG ELECTRONICS CO., LTD. (KR) 2020-02-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200044168-A1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING CONDENSED CYCLIC COMPOUND CRY1, CCNL2, CCNE2 PTGER4 553/4885RORC 1486/4885CYP11B1 1222/4885
US-11201300-B2 Condensed cyclic compound and organic light-emitting device including condensed cyclic compound CRY1, CCNL2, CCNE2 PTGER4 553/4885RORC 1486/4885CYP11B1 1222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.