Adenine

Adenine

SCHEMBL2168804

Nc1ncnc2nc[nH]c12.O=P(O)(O)OC1O[C@H](CO)[C@@H](O)[C@@H]1O

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 2/20 0.47
PI4K2B Q8TCG2 2/20 0.47
PI4K2A Q9BTU6 2/20 0.47
PI4KB Q9UBF8 2/20 0.47
LMNA P02545 1/20 0.47
DRD3 P35462 1/20 0.47
XDH P47989 1/20 0.47
LRRK2 Q5S007 1/20 0.47
ADORA1 P30542 1/20 0.46
HIF1A Q16665 1/20 0.41
RNASEL Q05823 1/20 0.39
FBP1 P09467 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mercaptopurine Anhydrous SCHEMBL10522158 0.87 ADORA1 (0.37) ADORA1
Adenine SCHEMBL580228 0.83 PI4KA (0.58) PI4KAPI4K2BPI4K2API4KBLMNA
Adenine SCHEMBL7624128 0.83 PI4KA (0.58) PI4KAPI4K2BPI4K2API4KBLMNA
Adenine SCHEMBL38386 0.83 PI4KA (0.58) PI4KAPI4K2BPI4K2API4KBLMNA
Adenine SCHEMBL7746165 0.83 PI4KA (0.58) PI4KAPI4K2BPI4K2API4KBLMNA
Dextrose SCHEMBL7886725 0.82 PI4KA (0.56) PI4KAPI4K2BPI4K2API4KBLMNA
Adenine SCHEMBL3921122 0.81 TRPM2 (0.49) PI4KAPI4K2BPI4K2API4KBLMNA
Adenine SCHEMBL11136514 0.81 TRPM2 (0.49) PI4KAPI4K2BPI4K2API4KBLMNA
Adenine SCHEMBL7996359 0.81 TRPM2 (0.49) PI4KAPI4K2BPI4K2API4KBLMNA
SCHEMBL1024249 0.80 ADORA1 (0.35) ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10787681-B2 Humanized viral vectors and methods of use thereof THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2020-09-29 US disclosed
CN-107890459-A Adenine arabinoside monophosphate freeze-dried powder injection and preparation method thereof 海南通用康力制药有限公司 2018-04-10 CN disclosed
CN-107890459-A Adenine arabinoside monophosphate freeze-dried powder injection and preparation method thereof 海南通用康力制药有限公司 2018-04-10 CN disclosed
US-20170128594-A1 Humanized Viral Vectors and Methods of Use Thereof THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) 2017-05-11 US disclosed
CN-101642440-B Vidarabine monophosphate freeze-dried powder injection for injection and preparation method thereof 广东隆赋药业股份有限公司 2016-12-21 CN disclosed
CN-101642440-B Vidarabine monophosphate freeze-dried powder injection for injection and preparation method thereof 广东隆赋药业股份有限公司 2016-12-21 CN disclosed
CN-102379853-B Vidarabine monophosphate freeze-dried powder injection and preparation method thereof HAINAN JINRUI PHARMACEUTICAL 2013-01-16 CN disclosed
CN-102389403-B Freeze dried monophosphate adenine arabinoside powder injection for injection and preparation method thereof GUANGZHOU LONGFU PHARMACEUTICAL CO LTD 2012-11-28 CN disclosed
CN-102389403-A Freeze dried monophosphate adenine arabinoside powder injection for injection and preparation method thereof GUANGZHOU LONGFU PHARMACEUTICAL CO LTD 2012-03-28 CN disclosed
CN-102379853-A Vidarabine monophosphate freeze-dried powder injection and preparation method thereof HAINAN JINRUI PHARMACEUTICAL 2012-03-21 CN disclosed
WO-1994027642-A1 HEPATOTROPIC CONJUGATES OF ANTIVIRAL DRUGS, CARRIERS THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM LABORATORI BALDACCI S.P.A. (IT) 1994-12-08 WO disclosed
EP-0624098-A1 PROCESS OF CONJUGATION OF ANTIVIRAL NUCLEOSIDES WITH LACTOSAMINATED HUMAN ALBUMIN LABORATORI BALDACCI Spa (IT) 1994-11-17 EP disclosed
US-5346696-A Recombinent Interferon KOREA GREEN CROSS CORPORATION (KR) 1994-09-13 US disclosed
WO-1994012218-A1 PROCESS OF CONJUGATION OF ANTIVIRAL NUCLEOSIDES WITH LACTOSAMINATED HUMAN ALBUMIN LABORATORI BALDACCI S.P.A. (IT) 1994-06-09 WO disclosed
WO-1993017651-A2 ANTIVIRAL NUCLEOSIDE ANALOGUES, THEIR PRODUCTION AND USE Max-Delbrück-Centrum für Molekulare Medizin (DE) 1993-09-16 WO disclosed
EP-0544878-A1 ASIALOGLYCOPROTEIN-CONJUGATED MEDICINAL AGENT COREA GREEN CROSS CORPORATION (KR) 1993-06-09 EP disclosed
WO-1992022310-A1 ASIALOGLYCOPROTEIN-CONJUGATED MEDICINAL AGENT LIVER RESEARCH FOUNDATION OF KOREA (KR) 1992-12-23 WO disclosed
EP-0472595-A4 METHOD OF TREATMENT OF HEPATITIS US COMMERCE (US) 1992-07-08 EP disclosed
EP-0472595-A1 METHOD OF TREATMENT OF HEPATITIS THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE (US) 1992-03-04 EP disclosed
WO-1990014079-A1 METHOD OF TREATMENT OF HEPATITIS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, UNITED STATES DEPARTMENT OF COMMERCE (US) 1990-11-29 WO disclosed