Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.65 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.59 |
| ▸ | HTR3B | O95264 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | HTR3A | P46098 | 1/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17279011 | 0.88 | MAPT (0.64) | MAPTSMN1; SMN2AKR1C3HTR3EHTR3B | |
| SCHEMBL9093746 | 0.87 | LMNA (0.71) | MAPTSMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL14982082 | 0.85 | MAPT (0.65) | MAPTSMN1; SMN2AKR1C3LMNAALDH1A1 | |
| SCHEMBL2898914 | 0.85 | MAPT (0.56) | MAPTSMN1; SMN2AKR1C3HTR3EHTR3B | |
| SCHEMBL870704 | 0.85 | HTR3E (0.70) | MAPTSMN1; SMN2AKR1C3HTR3EHTR3B | |
| SCHEMBL29998630 | 0.85 | HTR3E (0.70) | MAPTSMN1; SMN2AKR1C3HTR3EHTR3B | |
| SCHEMBL24103508 | 0.80 | SIGMAR1 (0.64) | MAPTSMN1; SMN2AKR1C3HTR3EHTR3B | |
| SCHEMBL2175616 | 0.80 | LMNA (0.62) | MAPTSMN1; SMN2LMNAALDH1A1MEN1 | |
| SCHEMBL1822749 | 0.80 | HTR3E (0.64) | MAPTSMN1; SMN2AKR1C3HTR3EHTR3B | |
| SCHEMBL1123884 | 0.80 | MAPT (0.57) | MAPTSMN1; SMN2AKR1C3LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113135835-A | Method for exciting C-C bond breaking acylation and application | 广州中医药大学(广州中医药研究院) | 2021-07-20 | — | — | CN | claimed |
| CN-118271158-B | Method for synthesizing deuterium-labeled substance containing deuterium atom structural unit | 山东大学 | 2026-05-12 | — | — | CN | disclosed |
| CN-118271158-A | Method for synthesizing deuterium-labeled substance containing deuterium atom structural unit | 山东大学 | 2024-07-02 | — | — | CN | disclosed |
| CN-115215816-B | Synthesis method of lactam compound | 普济生物科技（台州）有限公司 | 2024-02-02 | — | — | CN | disclosed |
| WO-2023243522-A1 | METHOD FOR PRODUCING AROMATIC COMPOUND | 日本化学工業株式会社 | 2023-12-21 | — | — | WO | disclosed |
| CN-115215816-A | Synthesis method of lactam compound | 普济生物科技（台州）有限公司 | 2022-10-21 | — | — | CN | disclosed |
| WO-2022218348-A1 | METHOD FOR SYNTHESIZING LACTAM COMPOUNDS | Seasons Biotechnology (Taizhou) Co., Ltd. (CN) | 2022-10-20 | — | — | WO | disclosed |
| CN-114786675-A | Small molecule bromodomain inhibitors and uses thereof | 康威基内有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113135835-B | Method for exciting C-C bond breaking acylation and application | 广州中医药大学(广州中医药研究院) | 2022-07-01 | — | — | CN | disclosed |
| CN-113072460-B | Morpholine derivative oxidation ring-opening method and product thereof | 西南大学 | 2022-06-24 | — | — | CN | disclosed |
| WO-2013131609-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-09-12 | — | — | WO | disclosed |
| WO-2013124026-A1 | 8 - SUBSTITUTED 2 -AMINO - [1,2,4] TRIAZOLO [1, 5 -A] PYRAZINES AS SYK TRYROSINE KINASE INHIBITORS AND GCN2 SERIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |
| US-20130225568-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | disclosed |
| EP-2609098-A1 | TRIAZOLOPYRAZINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| CN-103068828-A | Triazolopyrazine derivatives | MERCK PATENT GMBH | 2013-04-24 | — | — | CN | disclosed |
| CN-102532061-A | Method for easily preparing aryl morpholine and aryl piperidine | UNIV EAST CHINA SCIENCE & TECH | 2012-07-04 | — | — | CN | disclosed |
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |
| US-5773437-A | UROGENITAL DISORDERS SUCH AS DYSURIA | NIPPON CHEMIPHAR CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| CN-1148853-A | Alkylenediamine derivatives | NIPPON CHEMIPHAR CO (JP) | 1997-04-30 | — | — | CN | disclosed |
| CN-1024317-C | Antifungal agents based on amides containing phenyl group | RHONE POULENC AGROCHIMIE (FR) | 1994-04-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225568-A1 | TRIAZOLOPYRAZINE DERIVATIVES | SYK, IRAK1, ZAP70 | MAPT 4687/4885SMN1; SMN2 4628/4885AKR1C3 2736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.