Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 1/20 | 0.62 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.53 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413843 | 0.95 | F2RL1 (0.68) | F2RL1FFAR1ALDH1A1POLBNFKB1 | |
| SCHEMBL11904891 | 0.90 | F2RL1 (0.62) | F2RL1FFAR1ALDH1A1POLBNFKB1 | |
| SCHEMBL2172243 | 0.86 | FFAR1 (0.53) | F2RL1PARP10FFAR1ALDH1A1MAPT | |
| SCHEMBL659052 | 0.86 | ALOX5 (0.68) | F2RL1ALDH1A1POLBTAAR1ALOX5 | |
| SCHEMBL2173032 | 0.84 | FFAR1 (0.74) | PARP10FFAR1SMN1; SMN2 | |
| SCHEMBL20019549 | 0.84 | ALOX5 (0.61) | F2RL1POLBTAAR1ALOX5 | |
| SCHEMBL13522667 | 0.83 | ALOX5 (0.59) | F2RL1POLBTAAR1ALOX5 | |
| SCHEMBL933946 | 0.83 | ALOX5 (0.59) | F2RL1POLBTAAR1ALOX5 | |
| SCHEMBL2170992 | 0.83 | FFAR1 (0.53) | PARP10FFAR1SLC5A1SLC5A2 | |
| SCHEMBL2171661 | 0.83 | FFAR1 (0.53) | FFAR1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |