Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16020845 | 0.85 | DRD2 (0.34) | SLC6A4ACHERAB9AHSD17B2 | |
| SCHEMBL21697612 | 0.84 | SMN1; SMN2 (0.37) | HTR2AHTR2CSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL20741824 | 0.83 | ABCB1 (0.41) | SLC6A4SLC6A2SLC6A3ACHERAB9A | |
| SCHEMBL21697537 | 0.82 | MRGPRX4 (0.36) | SLC6A4SLC6A2SLC6A3RAB9ASMN1; SMN2 | |
| SCHEMBL16018642 | 0.79 | HSD17B2 (0.36) | SLC6A4SLC6A2ALOX5APHSD17B2 | |
| SCHEMBL21697640 | 0.79 | AGXT (0.40) | HTR2AHTR2CSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL20141585 | 0.76 | HTR2A (0.42) | HTR2AHTR2CSLC6A4SLC6A2SLC6A3 | |
| SCHEMBL21697652 | 0.76 | THRB (0.38) | SLC6A4SLC6A2SLC6A3SMN1; SMN2DRD1 | |
| SCHEMBL21697589 | 0.74 | PTGER1 (0.37) | RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL21697564 | 0.74 | FFAR1 (0.37) | HTR2AHTR2CACHERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968258-B1 | DUAL SGLT1/SGLT2 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-02-12 | — | — | EP | disclosed |