Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.39 |
| ▸ | ABAT | P80404 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LOX | P28300 | 1/20 | 0.34 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63659 | 0.77 | HRH3 (0.46) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL29760412 | 0.77 | HRH3 (0.46) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL13760885 | 0.74 | LOXL2 (0.46) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL13761189 | 0.74 | CSNK2A1 (0.46) | HRH3LOXL2PNMTCYP2A6TAAR1 | |
| SCHEMBL8018987 | 0.74 | HRH3 (0.39) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL2007285 | 0.71 | LOXL2 (0.48) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL28835049 | 0.71 | PNMT (0.41) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL13443566 | 0.71 | HRH3 (0.40) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL8141320 | 0.71 | HRH3 (0.40) | HRH3LOXL2ABATPNMTENPP2 | |
| SCHEMBL2006591 | 0.71 | CSNK2A1 (0.52) | HRH3LOXL2PNMTTAAR1LOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2729443-B3 | BENZYLAMINE DERIVATIVES AS INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-02-12 | — | — | EP | disclosed |