Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 4/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HTR1B | P28222 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL576035 | 0.85 | CA2 (0.50) | CXCR2CXCR1HSD11B1CA2CA1 | |
| SCHEMBL28726740 | 0.82 | CXCR2 (0.44) | CXCR2CXCR1HSD11B1CA2CA1 | |
| SCHEMBL26549561 | 0.80 | HSD11B1 (0.43) | HSD11B1CA2CA1CA9DRD2 | |
| SCHEMBL2750188 | 0.79 | CA2 (0.57) | CXCR2CXCR1HSD11B1CA2CA1 | |
| SCHEMBL1997269 | 0.79 | CA1 (0.57) | CXCR2CXCR1HSD11B1CA2CA1 | |
| SCHEMBL1713465 | 0.79 | KIF11 (0.55) | CXCR2CXCR1HSD11B1CA2CA1 | |
| SCHEMBL5179823 | 0.79 | PTPN1 (0.53) | CXCR2CXCR1HSD11B1CA2CA1 | |
| Iodide SCHEMBL1859836 | 0.78 | CA1 (0.55) | CXCR2CXCR1HSD11B1CA2CA1 | |
| Hydrogen Sulfide SCHEMBL6248782 | 0.78 | CA2 (0.55) | CXCR2CXCR1HSD11B1CA2CA1 | |
| Hydrogen Sulfide SCHEMBL5082548 | 0.78 | CA1 (0.55) | CXCR2CXCR1HSD11B1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105259-B | Method for removing sulfinyl in heteroarene compound | 浙江师范大学 | 2020-08-18 | — | — | CN | claimed |
| EP-3013787-A1 | TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES | Council of Scientific & Industrial Research (IN) | 2016-05-04 | — | — | EP | claimed |
| WO-2015128878-A1 | NOVEL BENZOXAPHOSPHOLE COMPOUNDS AND A PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2015-09-03 | — | — | WO | claimed |
| WO-2014207761-A1 | TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-12-31 | — | — | WO | claimed |
| CN-111548269-B | Preparation method of diaryl methane structural compound | 兰州大学 | 2023-10-27 | — | — | CN | disclosed |
| CN-115448941-A | Preparation method of allyl substituted aryl organosilicon compound | 青海师范大学 | 2022-12-09 | — | — | CN | disclosed |
| CN-110015942-B | Method for directly synthesizing biaryl compound without metal catalysis | 浙江师范大学 | 2021-12-24 | — | — | CN | disclosed |
| CN-111548269-A | Preparation method of diarylmethane structure compound | 兰州大学 | 2020-08-18 | — | — | CN | disclosed |
| EP-3013787-A1 | TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES | Council of Scientific & Industrial Research (IN) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014207761-A1 | TRANSITION-METAL-FREE N-ARYLATION OF TERTIARY AMINES USING ARYNES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-12-31 | — | — | WO | disclosed |
| EP-2346863-A2 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS | Elan Pharmaceuticals Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010028213-A2 | N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2010-03-11 | — | — | WO | disclosed |
| EP-1979324-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |