Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21701582 | 0.85 | KEAP1 (0.46) | RAB9AKMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL21701489 | 0.79 | MAPT (0.57) | RAB9AKMT2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL21701575 | 0.78 | MYC (0.43) | SMN1; SMN2RAB9AKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8125365 | 0.77 | ALDH1A1 (0.60) | SMN1; SMN2RAB9AKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL8124983 | 0.71 | NPSR1 (0.56) | SMN1; SMN2KMT2AKDM4ENPC1TSHR | |
| SCHEMBL7773522 | 0.69 | IP6K1 (0.52) | SMN1; SMN2RAB9AKMT2AALDH1A1POLB | |
| SCHEMBL2074046 | 0.68 | GAA (0.64) | SMN1; SMN2KMT2AL3MBTL1ALDH1A1POLB | |
| SCHEMBL1939077 | 0.68 | RAB9A (0.60) | SMN1; SMN2RAB9AKMT2AALDH1A1POLB | |
| SCHEMBL10688196 | 0.67 | KEAP1 (0.57) | SMN1; SMN2RAB9AKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9312757 | 0.67 | KEAP1 (0.57) | SMN1; SMN2RAB9AKMT2AL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020033944-A2 | NON-POLYAMINE BASED POLYAMINE TRANSPORT INHIBITORS AND THEIR USE IN THE TREATMENT OF HUMAN CANCERS | UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. (US) | 2020-02-13 | — | — | WO | disclosed |