Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 7/20 | 0.58 |
| ▸ | RHEB | Q15382 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.47 |
| ▸ | PNLIP | P16233 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171471 | 0.89 | FFAR1 (0.65) | FFAR1ACACBPNLIPTTR | |
| SCHEMBL4094627 | 0.80 | CDK8 (0.55) | — | |
| SCHEMBL2173032 | 0.79 | FFAR1 (0.74) | FFAR1FFAR4 | |
| SCHEMBL10088502 | 0.77 | TTR (0.70) | FFAR1RHEBPNLIPMRGPRX4TTR | |
| SCHEMBL30851410 | 0.77 | DPP4 (0.56) | FFAR1TTR | |
| SCHEMBL3393678 | 0.75 | PYGL (0.57) | FFAR1 | |
| SCHEMBL13218234 | 0.75 | ALDH1A1 (0.53) | FFAR1ACACBPNLIPMRGPRX4TTR | |
| SCHEMBL27486876 | 0.75 | PARP10 (0.59) | RHEBPNLIPMRGPRX4TTR | |
| SCHEMBL16316319 | 0.74 | TTR (0.51) | FFAR1TTR | |
| SCHEMBL2352325 | 0.74 | FFAR1 (0.76) | FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010045580-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | EXELIXIS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |