Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11051641 | 0.72 | MAPT (0.40) | MAPTALDH1A1SMN1; SMN2KDM4EGLA | |
| SCHEMBL4866544 | 0.70 | CHRM3 (0.34) | MAPTALDH1A1OPRM1FAAHMEN1 | |
| SCHEMBL4866159 | 0.68 | OPRD1 (0.41) | MAPTOPRD1KCNH2MEN1KMT2A | |
| SCHEMBL4957427 | 0.68 | KMT2A (0.39) | MAPTNR1H2NR1H3ALDH1A1SMN1; SMN2 | |
| SCHEMBL4867357 | 0.66 | KMT2A (0.40) | NR1H2NR1H3ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL4954835 | 0.66 | OPRD1 (0.38) | MAPTALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL26227072 | 0.65 | MAPT (0.37) | MAPTNR1H2NR1H3ALDH1A1SMN1; SMN2 | |
| SCHEMBL3965578 | 0.64 | MCL1 (0.40) | MAPTALDH1A1KDM4E | |
| SCHEMBL8217458 | 0.64 | HPGD (0.46) | ALDH1A1TSHROPRK1KCNH2MEN1 | |
| Hydrochloric Acid SCHEMBL4304994 | 0.64 | MCL1 (0.39) | MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973037-B2 | Cathepsin cysteine protease inhibitors | AXYS PHARMACEUTICALS, INC. (US) | 2011-07-05 | — | — | US | disclosed |