Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 4/20 | 0.35 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4304994 | 0.99 | MCL1 (0.39) | MCL1BCL2L1ADAMTS4ALDH1A1MAPT | |
| SCHEMBL4957427 | 0.65 | KMT2A (0.39) | ALDH1A1MAPTKDM4E | |
| SCHEMBL2163020 | 0.64 | GPR88 (0.44) | MCL1BCL2L1ALDH1A1MAPTHPGD | |
| SCHEMBL2170767 | 0.64 | MAPT (0.37) | ALDH1A1MAPTKDM4E | |
| SCHEMBL26227072 | 0.62 | MAPT (0.37) | ALDH1A1MAPTSLC6A2 | |
| SCHEMBL5132083 | 0.62 | MMP2 (0.54) | MCL1ALDH1A1MAPTMMP2MMP9 | |
| SCHEMBL5131313 | 0.62 | MMP2 (0.54) | MCL1ALDH1A1MAPTMMP2MMP9 | |
| SCHEMBL2163024 | 0.62 | GPR88 (0.56) | ALDH1A1GPR88 | |
| SCHEMBL27654625 | 0.60 | ALDH1A1 (0.60) | ALDH1A1MAPTHPGDGPR88KDM4E | |
| SCHEMBL16933577 | 0.60 | SMN1; SMN2 (0.51) | MCL1ADAMTS4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706402-A4 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2009-03-18 | — | — | EP | claimed |
| EP-1706402-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-10-04 | — | — | EP | claimed |
| WO-2005066159-A1 | CATHEPSIN CYSTEINE PROTEASE INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2005-07-21 | — | — | WO | claimed |
| US-20090176859-A1 | Cathepsin cysteine protease inhibitors | MERCK FROSST CANADA, LTD. (CA) | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176859-A1 | Cathepsin cysteine protease inhibitors | CTSE, CTSB, CTSS | MCL1 2228/4885BCL2L1 590/4885ADAMTS4 2987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.