Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Coumarin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 9/20 | 0.74 |
| ▸ | CA9 | Q16790 | 9/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.74 |
| ▸ | CA1 | P00915 | 4/20 | 0.74 |
| ▸ | CA3 | P07451 | 4/20 | 0.74 |
| ▸ | CA4 | P22748 | 4/20 | 0.74 |
| ▸ | CA5A | P35218 | 4/20 | 0.74 |
| ▸ | CA7 | P43166 | 4/20 | 0.74 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.74 |
| ▸ | CA5B | Q9Y2D0 | 4/20 | 0.74 |
| ▸ | CA2 | P00918 | 3/20 | 0.74 |
| ▸ | CA6 | P23280 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Coumarin SCHEMBL25431834 | 0.86 | CA12 (0.91) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL6252 | 0.86 | CA12 (1.00) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL29385611 | 0.86 | CA12 (1.00) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL3441294 | 0.86 | CA12 (1.00) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL621751 | 0.86 | CA12 (1.00) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL1038138 | 0.86 | CA12 (1.00) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL28886137 | 0.86 | CA12 (1.00) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL11101317 | 0.84 | CA12 (0.87) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL2301559 | 0.84 | CA12 (0.95) | CA12CA9MCL1CA1CA3 | |
| Coumarin SCHEMBL531571 | 0.84 | CA12 (0.95) | CA12CA9MCL1CA1CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210145747-A1 | CERASOME DELIVERY SYSTEM FOR TARGETING ACTIVATED CD44 MOLECULE, PREPARATION METHOD AND USE THEREOF | BEIJING INNO MEDICINE CO., LTD. (CN) | 2021-05-20 | — | — | US | claimed |
| US-20200397926-A1 | LIPOSOMAL NANOCARRIER DELIVERY SYSTEM FOR TARGETING ACTIVE CD44 MOLECULE,PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING INNO MEDICINE CO., LTD. (CN) | 2020-12-24 | — | — | US | claimed |
| EP-3744317-A1 | LIPOSOMAL NANOCARRIER DELIVERY SYSTEM FOR TARGETING ACTIVE CD44 MOLECULE, PREPARATION METHOD THEREFOR, AND USES THEREOF | Beijing Inno Medicine Co., Ltd. (CN) | 2020-12-02 | — | — | EP | claimed |
| EP-3610859-A1 | CERASOME DELIVERY SYSTEM FOR USE IN TARGETED ACTIVATION OF CD44 MOLECULE, PREPARATION METHOD THEREFOR AND USE | Beijing Inno Medicine Co., Ltd. (CN) | 2020-02-19 | — | — | EP | claimed |
| US-20240148913-A1 | LIPOSOMAL NANOCARRIER DELIVERY SYSTEM FOR TARGETING ACTIVE CD44 MOLECULE,PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING INNO MEDICINE CO., LTD. (CN) | 2024-05-09 | — | — | US | disclosed |
| US-11737977-B2 | Cerasome delivery system for targeting activated CD44 molecule, preparation method and use thereof | BEIJING INNO MEDICINE CO., LTD. (CN) | 2023-08-29 | — | — | US | disclosed |
| US-20210145747-A1 | CERASOME DELIVERY SYSTEM FOR TARGETING ACTIVATED CD44 MOLECULE, PREPARATION METHOD AND USE THEREOF | BEIJING INNO MEDICINE CO., LTD. (CN) | 2021-05-20 | — | — | US | disclosed |
| US-20200397926-A1 | LIPOSOMAL NANOCARRIER DELIVERY SYSTEM FOR TARGETING ACTIVE CD44 MOLECULE,PREPARATION METHOD THEREFOR, AND USES THEREOF | BEIJING INNO MEDICINE CO., LTD. (CN) | 2020-12-24 | — | — | US | disclosed |
| EP-3744317-A1 | LIPOSOMAL NANOCARRIER DELIVERY SYSTEM FOR TARGETING ACTIVE CD44 MOLECULE, PREPARATION METHOD THEREFOR, AND USES THEREOF | Beijing Inno Medicine Co., Ltd. (CN) | 2020-12-02 | — | — | EP | disclosed |
| EP-3610859-A1 | CERASOME DELIVERY SYSTEM FOR USE IN TARGETED ACTIVATION OF CD44 MOLECULE, PREPARATION METHOD THEREFOR AND USE | Beijing Inno Medicine Co., Ltd. (CN) | 2020-02-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210145747-A1 | CERASOME DELIVERY SYSTEM FOR TARGETING ACTIVATED CD44 MOLECULE, PREPARATION METHOD AND USE THEREOF | CD44, LDLR, PLAUR | CA12 469/4885CA9 1406/4885MCL1 1611/4885 |
| US-11737977-B2 | Cerasome delivery system for targeting activated CD44 molecule, preparation method and use thereof | CD44, LDLR, PLAUR | CA12 469/4885CA9 1406/4885MCL1 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.