Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL5161680 | 0.82 | TSHR (0.64) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL5161687 | 0.82 | TSHR (0.64) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Fumaric Acid SCHEMBL27642171 | 0.79 | TSHR (0.67) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| Maleic Acid SCHEMBL19691762 | 0.78 | TSHR (0.69) | ALDH1A1TSHRTP53EGLN1EGLN3 | |
| SCHEMBL6543250 | 0.77 | — | — | |
| SCHEMBL28330532 | 0.74 | ALDH1A1 (1.00) | ALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL78819 | 0.74 | — | — | |
| SCHEMBL11405021 | 0.74 | — | — | |
| SCHEMBL4221772 | 0.74 | — | — | |
| SCHEMBL4221767 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3611227-B1 | CURABLE RESIN COMPOSITION, FUEL CELL USING SAME, AND SEALING METHOD | THREE BOND CO LTD (JP) | 2022-12-21 | — | — | EP | disclosed |
| US-11114679-B2 | Curable resin composition, and fuel cell and sealing method using the same | THREEBOND CO., LTD. (JP) | 2021-09-07 | — | — | US | disclosed |
| US-20200321634-A1 | CURABLE RESIN COMPOSITION, AND FUEL CELL AND SEALING METHOD USING THE SAME | THREEBOND CO., LTD. (JP) | 2020-10-08 | — | — | US | disclosed |
| EP-3611227-A1 | CURABLE RESIN COMPOSITION, FUEL CELL USING SAME, AND SEALING METHOD | ThreeBond Co., Ltd. (JP) | 2020-02-19 | — | — | EP | disclosed |