Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5161687 | 1.00 | TSHR (0.64) | TSHRTP53EGLN1EGLN3LMNA | |
| SCHEMBL6543250 | 0.87 | — | — | |
| Maleic Acid SCHEMBL21708404 | 0.82 | ALDH1A1 (0.56) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL10792716 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL10792729 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL3777151 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL344296 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Maleic Acid SCHEMBL344295 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL16234752 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA | |
| Fumaric Acid SCHEMBL11408233 | 0.81 | TSHR (0.82) | TSHRTP53EGLN1EGLN3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1302336-C | Photographic processing system | FUJI PHOTO FILM CO LTD (JP) | 2007-02-28 | — | — | CN | disclosed |
| EP-1457817-B1 | Granulated solid processing agent for silver halide photographic material and producing method of the same | FUJI PHOTO FILM CO LTD (JP) | 2007-02-14 | — | — | EP | disclosed |
| US-7135275-B2 | Solid bleach-fixing composition for silver halide color photographic light-sensitive material, and method for processing silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. (JP) | 2006-11-14 | — | — | US | disclosed |
| CN-1284041-C | Solid bleach-fixing composition for silver halide color photographic light-sensitive material, and method for processing silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO LTD (JP) | 2006-11-08 | — | — | CN | disclosed |
| US-6949331-B2 | Method of reusing photographic processing waste solution, and photographic processing agent | FUJI PHOTO FILM CO., LTD. (JP) | 2005-09-27 | — | — | US | disclosed |
| US-6893807-B2 | Photographic processing system | FUJI PHOTO FILM CO., LTD. (JP) | 2005-05-17 | — | — | US | disclosed |
| US-20050069820-A1 | Thin film evaporating concentrator, method of evaporating and solidifying photographic waste solution, and reuse method of photographic waste solution | FUJI PHOTO FILM CO., LTD. | 2005-03-31 | — | — | US | disclosed |
| EP-1519225-A2 | Thin film evaporating concentrator, method of evaporating and solidifying photographic waste solution, and reuse method of photographic waste solution | FUJI PHOTO FILM CO., LTD. (JP) | 2005-03-30 | — | — | EP | disclosed |
| US-20050053873-A1 | Solid bleach-fixing composition for silver halide color photographic light-sensitive material, and method for processing silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO., LTD. | 2005-03-10 | — | — | US | disclosed |
| CN-1591179-A | Solid bleach-fixing composition for silver halide color photographic light-sensitive material, and method for processing silver halide color photographic light-sensitive material | FUJI PHOTO FILM CO LTD (JP) | 2005-03-09 | — | — | CN | disclosed |
| EP-1113320-B1 | Granulated solid processing agent for silver halide photographic material and producing method of the same | FUJI PHOTO FILM CO LTD (JP) | 2005-03-02 | — | — | EP | disclosed |
| US-20040229172-A1 | Method of reusing photographic processing wastesolution, and photographic processing agent | FUJIFILM CORPORATION (JP) | 2004-11-18 | — | — | US | disclosed |
| EP-1457817-A1 | Granulated solid processing agent for silver halide photographic material and producing method of the same | FUJI PHOTO FILM CO., LTD. (JP) | 2004-09-15 | — | — | EP | disclosed |
| US-20040175661-A1 | Granular solid photographic processing agent and production method thereof | FUJI PHOTO FILM CO., LTD. (JP) | 2004-09-09 | — | — | US | disclosed |
| EP-1455226-A1 | Granular solid photographic processing agent and production method thereof | FUJI PHOTO FILM CO., LTD. (JP) | 2004-09-08 | — | — | EP | disclosed |
| CN-1484092-A | Photographic processing system | 富士胶片株式会社 | 2004-03-24 | — | — | CN | disclosed |
| US-20040052517-A1 | Photographic processing system | FUJIFILM CORPORATION (JP) | 2004-03-18 | — | — | US | disclosed |
| US-6524780-B2 | Core/shell type spherical granule with an internal nucleus with a critical relative humidity of 70% or less; and one or more layers coating the nucleus | FUJI PHOTO FILM CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| US-20010044081-A1 | Granulated solid processing agent for silver halide photographic material and producing method of the same | FUJIFILM CORPORATION (JP) | 2001-11-22 | — | — | US | disclosed |
| EP-1113320-A2 | Granulated solid processing agent for silver halide photographic material and producing method of the same | FUJI PHOTO FILM CO., LTD. (JP) | 2001-07-04 | — | — | EP | disclosed |