Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 10/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 10/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2170838 | 0.85 | P2RX3 (0.58) | P2RX3P2RX2 | |
| SCHEMBL2173507 | 0.83 | WDR5 (0.49) | P2RX3P2RX2 | |
| SCHEMBL2171429 | 0.83 | P2RX3 (0.46) | P2RX3P2RX2P2RX7 | |
| SCHEMBL2171425 | 0.82 | NR1I2 (0.48) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2171681 | 0.75 | P2RX3 (0.61) | P2RX3P2RX2 | |
| SCHEMBL3660372 | 0.75 | P2RX3 (0.45) | P2RX3P2RX2 | |
| SCHEMBL14837447 | 0.74 | P2RX3 (0.45) | P2RX3P2RX2NR1I2 | |
| SCHEMBL638720 | 0.74 | P2RX3 (0.74) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2171464 | 0.73 | P2RX3 (0.51) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2171775 | 0.73 | P2RX3 (0.43) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010033168-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2010-03-25 | — | — | WO | disclosed |