Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.51 |
| ▸ | P2RX2 | Q9UBL9 | 7/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171460 | 0.85 | P2RX3 (0.61) | P2RX3P2RX2NR1I2TRPV1CYP2C9 | |
| SCHEMBL638720 | 0.76 | P2RX3 (0.74) | P2RX3P2RX2NR1I2 | |
| SCHEMBL3660372 | 0.76 | P2RX3 (0.45) | P2RX3P2RX2 | |
| SCHEMBL15936386 | 0.75 | P2RX3 (0.44) | P2RX3P2RX2NR1I2CYP2C9 | |
| SCHEMBL14837447 | 0.75 | P2RX3 (0.45) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2170842 | 0.73 | P2RX3 (0.43) | P2RX3P2RX2NR1I2 | |
| SCHEMBL3659404 | 0.71 | P2RX3 (0.43) | P2RX3P2RX2 | |
| SCHEMBL16495601 | 0.71 | HPGDS (0.49) | CYP2C9 | |
| SCHEMBL310920 | 0.70 | P2RX3 (0.77) | P2RX3P2RX2 | |
| SCHEMBL15779639 | 0.69 | TRPV1 (0.80) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010033168-A2 | AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2010-03-25 | — | — | WO | disclosed |