SCHEMBL21709172

SCHEMBL21709172

CC1(C)Oc2ccc(C(O)CN)cc2O1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 5/20 0.47
TDP1 Q9NUW8 4/20 0.47
KDM4E B2RXH2 4/20 0.47
APEX1 P27695 3/20 0.47
MAPT P10636 3/20 0.47
RECQL P46063 3/20 0.47
TAAR1 Q96RJ0 3/20 0.47
ADRB3 P13945 3/20 0.47
HPGD P15428 2/20 0.47
LMNA P02545 2/20 0.47
MAPK1 P28482 2/20 0.47
ADRB2 P07550 2/20 0.47
ADRB1 P08588 2/20 0.47
ADRA2A P08913 2/20 0.47
ADRA2B P18089 2/20 0.47
ADRA2C P18825 2/20 0.47
ADRA1D P25100 2/20 0.47
MEN1 O00255 1/20 0.47
ADORA3 P0DMS8 1/20 0.47
DRD2 P14416 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2012341 0.79 NFKB1 (0.41) BLMTDP1KDM4EAPEX1MAPT
SCHEMBL1204929 0.79 NFKB1 (0.41) BLMTDP1KDM4EAPEX1MAPT
SCHEMBL1205580 0.79 NFKB1 (0.41) BLMTDP1KDM4EAPEX1MAPT
SCHEMBL9141282 0.79 ALOX15 (0.50) BLMTDP1KDM4EAPEX1MAPT
SCHEMBL22764032 0.76 AOC3 (0.45) KDM4EMAPTADRB3HPGDADRB2
SCHEMBL22764035 0.76 NPC1 (0.51) BLMTDP1KDM4EAPEX1MAPT
SCHEMBL28699807 0.76 ALOX15 (0.40) ADRB3ADRB2ADRB1ADRA2AADRA2B
SCHEMBL13341027 0.74 TSHR (0.52) TDP1KDM4EMAPTHPGDLMNA
SCHEMBL21708851 0.74 AOC3 (0.40) TSHRALOX15ALOX12AOC3
SCHEMBL22764034 0.74 TSHR (0.38) MAPTHPGDLMNAMAPK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020032080-A1 COMPOUND, SALT OF COMPOUND, NEUROMODULATION AGENT, METHOD FOR EVALUATING NEUROMODULATION AGENT, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PRODUCING SALT OF COMPOUND 学校法人慶應義塾 2020-02-13 WO disclosed