SCHEMBL21709289

SCHEMBL21709289

CC(C)(C)[Si](C)(C)Oc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 10/20 0.74
MTNR1B P49286 7/20 0.54
KMT2A Q03164 2/20 0.54
ALDH1A1 P00352 2/20 0.54
KDM4E B2RXH2 1/20 0.54
MEN1 O00255 1/20 0.54
CYP1A1 P04798 1/20 0.54
MPO P05164 1/20 0.54
CYP1A2 P05177 1/20 0.54
CYP3A4 P08684 1/20 0.54
HTR1A P08908 1/20 0.54
CYP2D6 P10635 1/20 0.54
HPGD P15428 1/20 0.54
NQO2 P16083 1/20 0.54
HTR2B P41595 1/20 0.54
RAB9A P51151 1/20 0.54
BLM P54132 1/20 0.54
PMP22 Q01453 1/20 0.54
CYP1B1 Q16678 1/20 0.54
NOTUM Q6P988 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26989647 0.86 MTNR1A (0.55) MTNR1AMTNR1BKMT2AALDH1A1KDM4E
SCHEMBL9121109 0.85 MTNR1A (1.00) MTNR1AMTNR1BKMT2AALDH1A1KDM4E
SCHEMBL26989620 0.80 HTR1D (0.59) MTNR1AMTNR1BMPOHTR1A
SCHEMBL26989666 0.78 HTR2A (0.52) MTNR1AMTNR1BHTR1A
SCHEMBL21693925 0.78 HTR1A (0.65) KMT2AKDM4EMEN1CYP1A2CYP3A4
SCHEMBL6930033 0.77 MTNR1A (0.81) MTNR1AMTNR1BKMT2AALDH1A1KDM4E
SCHEMBL19244121 0.77 MTNR1A (0.56) MTNR1AMTNR1BKMT2AALDH1A1KDM4E
SCHEMBL26826208 0.74 MTNR1A (0.74) MTNR1AMTNR1BKMT2AALDH1A1KDM4E
SCHEMBL1972441 0.74 USP2 (0.77) MTNR1AKMT2AALDH1A1MEN1CYP1A2
SCHEMBL29991148 0.74 USP2 (0.77) MTNR1AKMT2AALDH1A1MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020032080-A1 COMPOUND, SALT OF COMPOUND, NEUROMODULATION AGENT, METHOD FOR EVALUATING NEUROMODULATION AGENT, METHOD FOR PRODUCING COMPOUND, AND METHOD FOR PRODUCING SALT OF COMPOUND 学校法人慶應義塾 2020-02-13 WO disclosed