Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.81 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.76 |
| ▸ | MPO | P05164 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.76 |
| ▸ | NQO2 | P16083 | 1/20 | 0.76 |
| ▸ | HTR2B | P41595 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | BLM | P54132 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.76 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.76 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9121109 | 0.89 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| Melatonin SCHEMBL4686085 | 0.86 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| Melatonin SCHEMBL29349848 | 0.86 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL28872503 | 0.86 | MTNR1A (0.83) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| Melatonin SCHEMBL8060688 | 0.86 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL23644935 | 0.86 | MTNR1A (0.83) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| Melatonin SCHEMBL19018 | 0.86 | MTNR1A (1.00) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL6927448 | 0.86 | MTNR1A (0.74) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL6924413 | 0.86 | MTNR1A (0.76) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 | |
| SCHEMBL7799780 | 0.86 | MTNR1A (0.78) | MTNR1AMTNR1BKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | claimed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | claimed |
| WO-2004085395-A1 | MELATONIN DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL DYSFUNCTIONS | FAUST PHARMACEUTICALS (FR) | 2004-10-07 | — | — | WO | disclosed |
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |