Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 7/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 6/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171034 | 0.87 | P2RX3 (0.39) | P2RX3P2RX2NR1I2HPGDSCTSA | |
| SCHEMBL2170986 | 0.85 | NR1I2 (0.45) | P2RX3P2RX2NR1I2HPGDSCTSA | |
| SCHEMBL2172981 | 0.83 | P2RX3 (0.39) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2172956 | 0.81 | NR1I2 (0.45) | P2RX3P2RX2NR1I2HPGDSCTSA | |
| SCHEMBL2171685 | 0.79 | S1PR3 (0.42) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2170462 | 0.77 | S1PR3 (0.41) | P2RX3P2RX2NR1I2HPGDS | |
| SCHEMBL2172263 | 0.77 | NSD2 (0.37) | P2RX3P2RX2 | |
| SCHEMBL2171499 | 0.77 | P2RX3 (0.61) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2171711 | 0.76 | CYP3A4 (0.46) | P2RX3P2RX2NR1I2HPGDSPTGS2 | |
| SCHEMBL2187309 | 0.76 | P2RX3 (0.56) | P2RX3P2RX2NR1I2CTSACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |