Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 6/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 7/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 7/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172000 | 0.87 | S1PR3 (0.40) | S1PR3P2RX3P2RX2S1PR1WNT3A | |
| SCHEMBL2172263 | 0.85 | NSD2 (0.37) | S1PR3P2RX3P2RX2GRM5 | |
| SCHEMBL2170462 | 0.85 | S1PR3 (0.41) | S1PR3P2RX3P2RX2S1PR1NR1I2 | |
| SCHEMBL2173127 | 0.81 | XDH (0.43) | S1PR3P2RX3P2RX2WNT3AGRM5 | |
| SCHEMBL2171780 | 0.79 | CYP11B2 (0.38) | S1PR3WNT3AXDH | |
| SCHEMBL2171503 | 0.79 | P2RX3 (0.43) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2172981 | 0.79 | P2RX3 (0.39) | P2RX3P2RX2NR1I2 | |
| SCHEMBL2171681 | 0.77 | P2RX3 (0.61) | P2RX3P2RX2 | |
| SCHEMBL2170747 | 0.75 | S1PR3 (0.40) | S1PR3S1PR1NR1I2WNT3A | |
| SCHEMBL2171994 | 0.73 | P2RX3 (0.46) | S1PR3P2RX3P2RX2S1PR1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |