Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171685 | 0.85 | S1PR3 (0.42) | S1PR3GRM5P2RX3P2RX2 | |
| SCHEMBL3476174 | 0.82 | GRM5 (0.43) | NSD2GRM5EGLN1OXTRCYP11B1 | |
| SCHEMBL2170462 | 0.81 | S1PR3 (0.41) | S1PR3GRM5MAP4K1P2RX3P2RX2 | |
| SCHEMBL2172261 | 0.78 | P2RX3 (0.59) | P2RX3P2RX2 | |
| SCHEMBL2171503 | 0.77 | P2RX3 (0.43) | P2RX3P2RX2 | |
| SCHEMBL2172981 | 0.77 | P2RX3 (0.39) | CYP11B2P2RX3P2RX2 | |
| SCHEMBL2172000 | 0.73 | S1PR3 (0.40) | S1PR3P2RX3P2RX2 | |
| SCHEMBL2171780 | 0.72 | CYP11B2 (0.38) | S1PR3CYP11B2SLC22A12 | |
| SCHEMBL3474932 | 0.67 | XDH (0.40) | GRM5P2RX3P2RX2 | |
| SCHEMBL2171034 | 0.66 | P2RX3 (0.39) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346825-A2 | MODULATORS OF P2X3 RECEPTOR ACTIVITY | Evotec AG (DE) | 2011-07-27 | — | — | EP | disclosed |