Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 6/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215872 | 0.82 | CHEK2 (0.55) | CHEK2ACHEFGFR1ALDH1A1KDM4E | |
| SCHEMBL213579 | 0.77 | LMNA (0.43) | CHEK2ACHEDYRK3MAP4K4PIM1 | |
| SCHEMBL217151 | 0.76 | CHEK2 (0.57) | CHEK2ACHEDYRK3MAP4K4PIM1 | |
| SCHEMBL214218 | 0.76 | ALDH1A1 (0.40) | ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL215714 | 0.76 | LMNA (0.42) | CHEK2ACHEDYRK3MAP4K4PIM1 | |
| SCHEMBL214151 | 0.74 | NPC1 (0.37) | ALDH1A1KDM4ELMNANPC1RAB9A | |
| SCHEMBL216746 | 0.72 | ACHE (0.57) | CHEK2ACHEFLT3PDGFRBPDGFRA | |
| SCHEMBL217150 | 0.69 | LMNA (0.50) | CHEK2ACHEDYRK3MAP4K4PIM1 | |
| SCHEMBL21018152 | 0.68 | ACHE (0.81) | CHEK2ACHEALDH1A1KDM4ELMNA | |
| SCHEMBL216399 | 0.67 | LMNA (0.45) | CHEK2ALDH1A1LMNAMAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088767-B2 | JAK-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-01-03 | — | — | US | disclosed |