Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 11/20 | 0.38 |
| ▸ | LOX | P28300 | 6/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.32 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1419347 | 0.92 | LOXL2 (0.38) | LOXL2LOXFDPS | |
| SCHEMBL3123975 | 0.85 | LOXL2 (0.50) | LOXL2LOXLOXL3 | |
| SCHEMBL1419723 | 0.84 | FDPS (0.42) | LOXL2LOXFDPS | |
| SCHEMBL10863486 | 0.82 | LOXL2 (0.35) | LOXL2LOXCA1CA2CA4 | |
| SCHEMBL3126373 | 0.80 | ALDH1A1 (0.33) | LOXL2LOXHRH2 | |
| SCHEMBL3121233 | 0.78 | LOXL2 (0.33) | LOXL2LOX | |
| SCHEMBL7993752 | 0.78 | LOXL2 (0.34) | LOXL2LOXCA1CA2CA4 | |
| Hydrochloric Acid SCHEMBL1870823 | 0.77 | FDPS (0.34) | LOXL2HRH4HRH3FDPS | |
| SCHEMBL1419367 | 0.74 | SMN1; SMN2 (0.36) | LOXL2LOX | |
| SCHEMBL26064714 | 0.71 | CA2 (0.41) | LOXL2LOXCA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346868-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010036632-A1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-01 | — | — | WO | disclosed |