Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2173674 | 0.86 | MAPT (0.46) | RIPK1CYP2C9ALDH1A1LMNACYP2C19 | |
| SCHEMBL1557963 | 0.77 | ALDH1A1 (0.44) | CYP2C9ALDH1A1LMNACYP2C19CYP2D6 | |
| SCHEMBL3232967 | 0.74 | ALDH1A1 (0.49) | CYP2C9ALDH1A1LMNACYP2C19CYP2D6 | |
| SCHEMBL3224087 | 0.73 | PPID (0.56) | CYP2C9ALDH1A1LMNASMN1; SMN2KMT2A | |
| SCHEMBL2171962 | 0.72 | SMN1; SMN2 (0.44) | RIPK1ALDH1A1LMNACYP2C19CYP2D6 | |
| SCHEMBL27869588 | 0.71 | ALDH1A1 (0.46) | CYP2C9ALDH1A1LMNACYP2C19CYP2D6 | |
| SCHEMBL34467582 | 0.71 | CYP2C9 (0.42) | CYP2C9ALDH1A1LMNACYP2C19CYP2D6 | |
| SCHEMBL3463439 | 0.70 | L3MBTL1 (0.44) | RIPK1CYP2C9ALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL10964253 | 0.69 | GAA (0.54) | ALDH1A1CYP2C19CYP3A4GAAKMT2A | |
| SCHEMBL13430499 | 0.69 | L3MBTL1 (0.39) | RIPK1ALDH1A1LMNACYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346871-A1 | ALPHA HELIX MIMETICS IN THE TREATMENT OF CANCER | PRISM BioLab Corporation (JP) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010044485-A1 | ALPHA HELIX MIMETICS IN THE TREATMENT OF CANCER | PRISM BIOLAB CORPORATION (JP) | 2010-04-22 | — | — | WO | disclosed |