Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171968 | 0.86 | RIPK1 (0.43) | LMNAMMP8SMN1; SMN2RIPK1ALDH1A1 | |
| SCHEMBL3224087 | 0.80 | PPID (0.56) | MAPTPPIDLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2173670 | 0.76 | PPID (0.51) | MAPTPPIDLMNAMMP8SMN1; SMN2 | |
| SCHEMBL17541033 | 0.72 | MMP8 (0.56) | MAPTPPIDLMNAMMP8SMN1; SMN2 | |
| SCHEMBL1557963 | 0.72 | ALDH1A1 (0.44) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL13430501 | 0.72 | PPID (0.46) | MAPTPPIDLMNASMN1; SMN2RIPK1 | |
| SCHEMBL7440971 | 0.70 | SMN1; SMN2 (0.56) | MAPTPPIDLMNAMMP8SMN1; SMN2 | |
| SCHEMBL2171018 | 0.70 | PPID (0.66) | MAPTPPIDLMNAMMP8SMN1; SMN2 | |
| SCHEMBL11501252 | 0.69 | NPC1 (0.41) | MAPTPPIDLMNASMN1; SMN2RIPK1 | |
| SCHEMBL3232967 | 0.69 | ALDH1A1 (0.49) | LMNASMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346871-A1 | ALPHA HELIX MIMETICS IN THE TREATMENT OF CANCER | PRISM BioLab Corporation (JP) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010044485-A1 | ALPHA HELIX MIMETICS IN THE TREATMENT OF CANCER | PRISM BIOLAB CORPORATION (JP) | 2010-04-22 | — | — | WO | disclosed |