Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 18/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 18/20 | 0.57 |
| ▸ | MMP2 | P08253 | 18/20 | 0.57 |
| ▸ | MMP9 | P14780 | 10/20 | 0.53 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2174326 | 1.00 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2173607 | 0.85 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2176396 | 0.85 | ADAM10 (0.62) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2175055 | 0.77 | ADAM10 (0.48) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2172763 | 0.75 | ADAM10 (0.75) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2174958 | 0.73 | ADAM10 (0.55) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2172999 | 0.73 | ADAM10 (0.74) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL2173731 | 0.73 | ADAM10 (0.74) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL5635351 | 0.73 | ADAM10 (0.74) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL5635349 | 0.73 | ADAM10 (0.74) | ADAM10ERBB2MMP2MMP9CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9440958-B2 | Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases | INCYTE CORPORATION (US) | 2016-09-13 | — | — | US | disclosed |
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION | 2011-09-15 | — | — | US | disclosed |
| US-7973041-B2 | Antiarthritic agents; psoriasis; anticancer agents;antiallergens; metalloprotease inhibitors. | INCYTE CORPORATION (US) | 2011-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224189-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | MMP25, MMP14, MMP9 | ADAM10 25/4885ERBB2 2986/4885MMP2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.