Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28049210 | 0.80 | NR3C2 (0.40) | CDC7LRRK2LMNAMAPK1MAPK9 | |
| SCHEMBL2991676 | 0.80 | LMNA (0.57) | HPGDSPARP1CHEK2MAP4K4CDC7 | |
| SCHEMBL3468178 | 0.80 | ADORA2A (0.50) | PARP1CDC7LMNACDK2KMT2A | |
| SCHEMBL4763130 | 0.75 | KMO (0.44) | CHEK2CDC7KMOPLK4AURKA | |
| SCHEMBL30668220 | 0.74 | MKNK1 (0.54) | CHEK2LMNAPIM1CYP1A2CYP3A4 | |
| SCHEMBL2228105 | 0.74 | MKNK1 (0.54) | CHEK2LMNAPIM1CYP1A2CYP3A4 | |
| SCHEMBL30665107 | 0.74 | MKNK1 (0.54) | CHEK2LMNAPIM1CYP1A2CYP3A4 | |
| SCHEMBL14152807 | 0.74 | EGLN1 (0.62) | HPGDSPARP1CHEK2MAP4K4LRRK2 | |
| SCHEMBL22551970 | 0.74 | HPGDS (0.50) | HPGDSPARP1CHEK2MAP4K4CDC7 | |
| SCHEMBL29907583 | 0.74 | HPGDS (0.50) | HPGDSPARP1CHEK2MAP4K4CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837250-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD (CN) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020035052-A1 | PYRAZINE COMPOUNDS AND USES THEREOF | DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD. (CN) | 2020-02-20 | — | — | WO | disclosed |