Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | RORB | Q92753 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28777525 | 0.88 | LMNA (0.49) | LMNAMAP4K4HPGDSCDC7PARP1 | |
| SCHEMBL30108258 | 0.83 | PARP1 (0.47) | LMNACDC7PARP1RPS6KB1ROCK2 | |
| SCHEMBL28225056 | 0.83 | PARP1 (0.47) | LMNACDC7PARP1RPS6KB1ROCK2 | |
| SCHEMBL27964788 | 0.82 | RORB (0.68) | PARP1RORBRPS6KB1JAK2PDE4A | |
| SCHEMBL18580116 | 0.82 | TLR8 (0.51) | MAP4K4CDC7PARP1RORBKMO | |
| SCHEMBL5178386 | 0.81 | PARP1 (0.58) | LMNAPARP1RORBRPS6KB1KMO | |
| SCHEMBL29916420 | 0.80 | KDM4E (0.55) | PARP1RORBJAK2MAPTHTT | |
| SCHEMBL945856 | 0.80 | KDM4E (0.55) | PARP1RORBJAK2MAPTHTT | |
| SCHEMBL21722362 | 0.80 | HPGDS (0.51) | LMNAMAP4K4HPGDSCDC7PARP1 | |
| SCHEMBL30359410 | 0.80 | MAPT (0.47) | LMNAMAP4K4PARP1RORBRPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | LMNA 1347/4885MAP4K4 2268/4885HPGDS 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.