Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.55 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504239 | 0.95 | MEN1 (0.60) | MEN1KMT2AHPGDTRPV1EPHX2 | |
| SCHEMBL15988002 | 0.83 | MEN1 (0.61) | MEN1KMT2AHPGDTRPV1POLB | |
| SCHEMBL26998806 | 0.80 | HPGD (0.59) | MEN1KMT2AHPGDALDH1A1HSD17B10 | |
| SCHEMBL8880319 | 0.80 | L3MBTL1 (0.59) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL1189665 | 0.79 | MAPT (0.66) | MEN1KMT2AHPGDTRPV1EPHX2 | |
| SCHEMBL30599557 | 0.79 | MAPT (0.66) | MEN1KMT2AHPGDTRPV1EPHX2 | |
| SCHEMBL5550015 | 0.78 | TSHR (0.55) | MEN1KMT2AHPGDPOLBMAPT | |
| SCHEMBL28709820 | 0.78 | KMT2A (0.69) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL27365595 | 0.78 | HPGD (0.59) | MEN1KMT2AHPGDMAPTALDH1A1 | |
| SCHEMBL5141417 | 0.78 | MEN1 (0.71) | MEN1KMT2AHPGDEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3836919-A1 | 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF | Recreo Pharmaceuticals Inc. (US) | 2021-06-23 | — | — | EP | disclosed |
| WO-2020037155-A1 | 1,3,4,9-TETRAHYDRO-2H-PYRIDO[3,4-B]INDOLE DERIVATIVE COMPOUNDS AND USES THEREOF | RECREO PHARMACEUTICALS LLC (US) | 2020-02-20 | — | — | WO | disclosed |