Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 14/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 9/20 | 0.45 |
| ▸ | TNNC1 | P63316 | 5/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.45 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.45 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.45 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31290840 | 0.89 | HTT (0.45) | — | |
| SCHEMBL2715741 | 0.89 | HTT (0.45) | — | |
| SCHEMBL9239878 | 0.84 | HTT (0.49) | — | |
| SCHEMBL28354766 | 0.84 | HTT (0.49) | — | |
| Tromethamine SCHEMBL7568694 | 0.83 | THRA (0.42) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Tromethamine SCHEMBL10928061 | 0.81 | S1PR1 (0.39) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| SCHEMBL29366175 | 0.79 | HTT (0.50) | — | |
| SCHEMBL125443 | 0.79 | HTT (0.50) | — | |
| SCHEMBL28058768 | 0.78 | HTT (0.43) | — | |
| Tromethamine SCHEMBL11416037 | 0.78 | THRA (0.49) | S1PR1S1PR3TNNC1S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831992-B | Polymerizable composition for optical material and molded article | 三井化学株式会社 | 2022-08-23 | — | — | CN | claimed |
| CN-110831992-A | Polymerizable composition for optical material and molded article | 三井化学株式会社 | 2020-02-21 | — | — | CN | claimed |
| CN-118302573-A | Aqueous adhesive, reinforcing fiber using the same, and elastomer product using the reinforcing fiber | 株式会社可乐丽 | 2024-07-05 | — | — | CN | disclosed |
| CN-118251527-A | Reinforcing fiber, method for producing same, and elastomer product using reinforcing fiber | 株式会社可乐丽 | 2024-06-25 | — | — | CN | disclosed |
| CN-112566981-B | Polycarbonate resin composition for 3D printing and filament for 3D printing comprising the same | 株式会社三养社 | 2023-10-10 | — | — | CN | disclosed |
| CN-113366078-B | Adhesive composition and surface protective film | DIC株式会社 | 2023-06-23 | — | — | CN | disclosed |
| CN-112996875-B | Adhesive composition and surface protective film | DIC株式会社 | 2023-05-26 | — | — | CN | disclosed |
| CN-116157256-A | Woven carpet tile and method of making same | 美国阿拉丁制造公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-113993964-B | Pressure-sensitive adhesive composition and surface protective film | DIC株式会社 | 2023-04-25 | — | — | CN | disclosed |
| CN-115989269-A | Reinforcing fiber and molded article using same | 株式会社可乐丽 | 2023-04-18 | — | — | CN | disclosed |
| CN-113527930-B | Photopolymer composition, grating and preparation method thereof | 杭州光粒科技有限公司 | 2023-04-07 | — | — | CN | disclosed |
| CN-113993964-A | Pressure-sensitive adhesive composition and surface protective film | DIC株式会社 | 2022-01-28 | — | — | CN | disclosed |
| CN-113557144-A | Method for manufacturing printed matter | 东丽株式会社 | 2021-10-26 | — | — | CN | disclosed |
| CN-113527930-A | Photopolymer composition, grating and preparation method thereof | 杭州光粒科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| CN-112996875-A | Adhesive composition and surface protective film | DIC株式会社 | 2021-06-18 | — | — | CN | disclosed |
| CN-112566981-A | Polycarbonate resin composition for 3D printing and filament for 3D printing comprising the same | 株式会社三养社 | 2021-03-26 | — | — | CN | disclosed |
| WO-2020246529-A1 | ADHESIVE COMPOSITION AND SURFACE PROTECTIVE FILM | DIC株式会社 | 2020-12-10 | — | — | WO | disclosed |
| CN-107001906-B | Ultraviolet-curable adhesive composition, method for producing ultraviolet-curable adhesive sheet, and method for producing laminate | DIC株式会社 | 2020-07-17 | — | — | CN | disclosed |
| CN-110831992-A | Polymerizable composition for optical material and molded article | 三井化学株式会社 | 2020-02-21 | — | — | CN | disclosed |
| WO-2020036333-A1 | POLYCARBONATE RESIN COMPOSITION FOR 3D PRINTING AND 3D PRINTING FILAMENT COMPRISING SAME | 주식회사 삼양사 | 2020-02-20 | — | — | WO | disclosed |